AI Article Synopsis
- The study investigates the impact of the G-1082A polymorphism in the IL-10 gene on the progression of two types of kidney diseases: IgA nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS).
- Patients were divided into slow and fast progressors based on their kidney function over time, revealing a connection between certain genotypes and faster disease progression.
- Findings indicate that the GA/AA genotypes are associated with worse kidney survival outcomes, making this polymorphism a potentially important marker for predicting disease progression in affected patients.
Article Abstract
Background: Interleukin-10 (IL-10) is a cytokine with immunosuppressive properties. We evaluated the influence of G-1082A polymorphism in the IL-10 gene promoter, which has been associated with modified IL-10 production, on the two most common forms of primary glomerulonephritis: IgA nephropathy (IgAN) and focal segmental glomerulosclerosis (FSGS).
Methods: We studied Caucasian patients (N= 191) with biopsy-proven glomerulonephritis (IgAN: N= 123, FSGS: N= 68) followed-up for 6.5 +/- 5.5 years. Patients were classified according to the slope of reciprocal serum creatinine (>/= or <-0.1 dL(*)mg(-1) (*)year(-1)) into group A (slow progressors, IgAN: N= 75, FSGS: N= 47) and group B (fast progressors, IgAN: N= 48, FSGS: N= 21). One hundred healthy volunteers were analyzed as control patients. G-1082A polymorphism was determined by polymerase chain reaction (PCR) amplification.
Results: The allele frequencies were similar in patients and control group (NS). Initial renal function, proteinuria, and blood pressure did not differ significantly between patients with different genotypes. G-1082A polymorphism was associated with the progression of both IgAN and FSGS: GA/AA genotypes were more frequent in group B (fast progressors) than in group A (slow progressors; P= 0.012 for IgAN, P < 0.05 for FSGS). Patients with the GA/AA genotypes showed a worse outcome in the Kaplan-Meier analysis of renal survival (P < 0.05 for both IgAN and FSGS). The IL-10 polymorphism remained an independent risk factor for progression in multivariate analysis (Cox regression model, P < 0.05 for IgAN and FSGS).
Conclusion: Our results suggest that IL-10 gene G-1082A polymorphism is an important marker of progression in patients with IgAN and FSGS.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1523-1755.2004.00730.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Physiologically Based Pharmacokinetic Approach to Recommend an Individual Dose of Tacrolimus in Adult Heart Transplant Recipients.
Pharmaceutics
November 2023
Department of Pharmacy, Nanjing First Hospital, China Pharmaceutical University, Nanjing 210006, China.
Tacrolimus is the principal immunosuppressive drug which is administered after heart transplantation. Managing tacrolimus therapy is challenging due to a narrow therapeutic index and wide pharmacokinetic (PK) variability. We aimed to establish a physiologically based pharmacokinetic (PBPK) model of tacrolimus in adult heart transplant recipients to optimize dose regimens in clinical practice.
View Article and Find Full Text PDFAdenoid Hypertrophy Risk in Children Carriers of G-1082A Polymorphism of Infected with Human Herpes Virus (HHV6, EBV, CMV).
Life (Basel)
February 2022
Department of Otolaryngology, Institute of Medicine, Peoples' Friendship University of Russia (RUDN University), 117198 Moscow, Russia.
Adenoid hypertrophy (AH) is considered one of the most common diseases in the ear, nose and throat (ENT) practice. The cause of adenoid hypertrophy in children is still unknown. The main aim of the current study was to investigate (interleukin 10) gene polymorphisms and human herpesviruses 6 (HHV6), cytomegalovirus (CMV), and Epstein-Barr virus (EBV) infections in children with AH.
View Article and Find Full Text PDFGenetic polymorphism in patients with early and late onset of ulcerative colitis.
Wiad Lek
March 2020
Shupyk National Medical Academy Of Postgraduate Education, Kyiv, Ukraine.
Objective: The aim was to investigate SNPs of TLR-2,3,4, NOD2/CARD15, JAK-2, and IL-10 in patients with the early and late UC onset.
Patients And Methods: Matherials and methods: 126 patients with UC were investigated. To assess the predisposition of the early and late UC onset the incidence of the following SNPs: Arg753Gln TLR2 gene, Phe412Leu TLR3 gene, Asp299Gly and Thr399Ile TLR4 gene, C-819T, G-1082A and C-592A gene IL-10, Val617Phe gene JAK2, Gly908Arg gene NOD2/CARD15 were analyzed.
[Analysis of the association of interleukin 4 and interleukin 10 gene variants with basic personality traits].
Mol Biol (Mosk)
March 2017
Mental Health Research Center, Moscow, 117152 Russia.
There is growing evidence that serum levels of various inflammation markers are associated with personality traits. However, only few studies investigated the link between genetic variants of cytokine encoding genes and psychological characteristics. In this study, we examined genotypes in 297 individuals to assess the association between common variants of interleukin 4 (IL-4) and interleukin 10 (IL-10) genes and basic personality traits of extraversion and neuroticism, measured using the Eysenck Personality Questionnaire (EPQ).
View Article and Find Full Text PDFRelationship between interleukin-10 (IL-10) gene G-1082A (rs1800896) polymorphism and the risk of development and stages of chronic lymphoid leukemia is studied in ethnic Russian residents of the Kirov region of Russia. Associations of allele -1082A and genotypes (-1082AA/-1082AG) with the risk of chronic lymphoid leukemia are detected (OR=1.39, 95%CI=1.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!