Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.200353609 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Asymmetric Amplification in Oxypalladation/Malononitrile Addition Cascade Enabled by Heterochiral-Assembly of Products.
Org Lett
January 2025
Hubei Research Center of Fundamental Science-Chemistry, Engineering Research Center of Organosilicon Compounds & Materials, Hubei Key Lab on Organic and Polymeric Optoelectronic Materials, and College of Chemistry and Molecular Sciences, Wuhan University, 299 Bayi Rd, Wuhan 430072, China.
An enantioselective oxypalladation/malononitrile addition cascade reaction of alkyne-tethered malononitriles was reported to synthesize enaminones bearing an all-carbon quaternary center. Using Pd(TFA)/Pyox as a precatalyst, an array of enaminone products were obtained in moderate overall yields, with excellent er (93.5:6.
View Article and Find Full Text PDFSelf-Interference Digital Optofluidic Genotyping for Integrated and Automated Label-Free Pathogen Detection.
ACS Sens
December 2024
School of Integrated Circuits and Electronics, Engineering Research Center of Integrated Acousto-Optoelectronic Microsystem (Ministry of Education of China), Beijing Institute of Technology, Beijing 100081, China.
Article Synopsis
- - Pathogens cause around 4.95 million deaths each year, and traditional detection methods like microscopy are outdated, slow, and often subjective.
- - Isothermal amplification techniques such as recombinase polymerase amplification (RPA) offer a faster alternative but struggle with specificity and automation.
- - This study presents a new optofluidic platform that uses advanced techniques for rapid, label-free pathogen detection, achieving high sensitivity and the ability to simultaneously identify multiple strains within 50 minutes.
A broad-spectrum peptide screening method using an optimized solid-phase extraction and liquid chromatography-high-field asymmetric ion mobility spectrometry-mass spectrometry for doping control in equine urine.
Anal Methods
December 2024
Laboratory of Racing Chemistry, 1731-2, Tsurutamachi, Utsunomiya, Japan.
The abuse of prohibited peptide-based drugs with a broad spectrum of chemical characteristics poses a significant concern for the horseracing industry. Recently, there has been a notable increase in positive cases of small-peptide drugs reported in equine and canine sports. In addition to small peptides, large peptides (over 2 kDa) with structural diversity have also entered the market in increasing numbers as drugs for humans and livestock.
View Article and Find Full Text PDFArticle Synopsis
- siRNA therapeutics have great potential for treating cancer, but effective delivery methods that reduce toxicity while promoting rapid cellular uptake have been difficult to develop.
- Our team created an innovative siRNA conjugate platform named "siRNA-L," which uses natural albumin in the bloodstream for targeted delivery to tumors without relying on traditional lipid or polymer methods.
- To enhance the effectiveness of siRNA-L, we synthesized a new conjugate called siRNA-CQ-L that incorporates chloroquine for better endosomal escape and higher gene silencing efficiency, showing no significant toxicity in mice while improving delivery and retention in cancer cells.
A new strategy for systematically classifying HLA alleles into serological specificities: Update and refinement.
HLA
October 2024
Histocompatibility and Immunogenetics Laboratory, Stanford Blood Center, Palo Alto, California, USA.
HLA antigens were historically defined according to the unique reactivity pattern of cells expressing HLA molecules with distinctive clusters of allo-antisera and/or monoclonal antibodies. Subsequently, amino acid residues determining epitopes (DEP) in the HLA molecule were correlated with reactivity patterns. In current clinical practice, the presence of allo-antibodies is assessed using Luminex-based solid phase single antigen bead (SAB) assays for transplantation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!