Migraine is a neurovascular syndrome characterized by recurrent headache associated with other symptoms, eventually preceded by aura. This chapter reviews the involvement of some mineral, coenzyme, and vitamin defects in the pathogenesis of migraine headaches and focuses on their potential therapeutic use in the preventive treatment for migraine. The therapeutic potential of magnesium, coenzyme Q(10), riboflavin, and vitamin B(12) can be cautiously inferred from some published open clinical trials; it should, however, be considered that double-blind randomized larger studies are needed to correctly estimate the impact of the placebo effect in these promising therapies.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/S0083-6729(04)69011-X | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Ligand binding characteristics of an NAD riboswitch revealed by FRET and biolayer interferometry.
Chem Commun (Camb)
December 2024
University of Oregon Department of Chemistry and Biochemistry, Eugene, USA.
The Class II NAD riboswitch is a bacterial RNA that binds ligands containing nicotinamide. Herein, we report a fluorescence and biolayer interferometry study of riboswitch interactions with β-NMN. The results reveal a shift in the prevalence of a pseudoknot structure in the presence of ligand and Mg.
View Article and Find Full Text PDFPractical supplements for prevention and management of migraine attacks: a narrative review.
Front Nutr
October 2024
Nutrition and Food Security Research Center, Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.
Background: Migraine is one of the most debilitating neurological disorders that causes frequent attacks of headaches and affects approximately 11% of the global population. Deficient or even insufficient levels of vital nutrients would increase the severity and frequency of migraine attacks. Therefore, we aimed to examine the practical supplements for the prevention and management of migraine attacks.
View Article and Find Full Text PDFMg binding to coenzyme A.
Arch Biochem Biophys
January 2025
Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, 11800, Uruguay; Centro de Investigaciones Biomédicas (CEINBIO), Universidad de la República, Montevideo, 11800, Uruguay. Electronic address:
Magnesium (Mg), the second most abundant intracellular cation, plays a crucial role in cellular functions. In this study, we investigate the interaction between Mg and coenzyme A (CoA), a thiol-containing cofactor central to cellular metabolism also involved in protein modifications. Isothermal titration calorimetry revealed a 1:1 binding stoichiometry between Mg and free CoA under biologically relevant conditions.
View Article and Find Full Text PDFMulti-omics analysis uncovers the transcriptional regulatory mechanism of magnesium Ions in the synthesis of active ingredients in Sophora tonkinensis.
Sci Rep
October 2024
Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Engineering Research Center of TCM Resource Intelligent Creation, National Center for TCM Inheritance and Innovation, Guangxi Botanical Garden of Medicinal Plants, Nanning, 530023, China.
Article Synopsis
- Magnesium is crucial for plant health as it is a key part of chlorophyll and acts as a coenzyme, but its regulatory role in secondary metabolite synthesis is not fully understood.
- The study focuses on Sophora tonkinensis, a medicinal plant in China, analyzing how different magnesium concentrations in tissue-cultured seedlings affect their secondary metabolites and overall growth.
- By using multi-omics data analysis, the research reveals the complex ways magnesium influences metabolic pathways, which in turn affects the levels of beneficial compounds and the growth of the plant.
High-throughput identification of calcium-regulated proteins across diverse proteomes.
Cell Rep
November 2024
Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Brotman Baty Institute for Precision Medicine, Seattle, WA, USA; Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA. Electronic address:
Calcium ions play important roles in nearly every biological process, yet whole-proteome analysis of calcium effectors has been hindered by a lack of high-throughput, unbiased, and quantitative methods to identify protein-calcium engagement. To address this, we adapted protein thermostability assays in budding yeast, human cells, and mouse mitochondria. Based on calcium-dependent thermostability, we identified 2,884 putative calcium-regulated proteins across human, mouse, and yeast proteomes.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!