Background: Respiratory infections are the leading cause of outpatient visits in the United States, but the etiology of many of these infections is unknown. Human metapneumovirus (hMPV) is a recently discovered virus that causes respiratory infections.
Methods: Respiratory specimens obtained from patients
Results: hMPV was detected in 6.2% of patients tested and was significantly more common among children 3-24 months old than in older or younger children. The seasonal occurrence of hMPV was similar to that of respiratory syncytial virus and influenza virus, with most cases occurring in the winter and spring. In this tertiary care-center population, patients with hMPV infection often had underlying chronic conditions.
Conclusions: hMPV is common among young children with apparent respiratory infections, suggesting that it is a significant cause of symptomatic respiratory infections.
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http://dx.doi.org/10.1086/421120 | DOI Listing |
QJM
January 2025
SR Sanjeevani Hospital, Kalyanpur-10, Siraha, Nepal.
Virology
January 2025
LKC School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore, 308232, Republic of Singapore.
Respiratory syncytial virus (RSV) particle assembly occurs on the surface of infected cells at specialized membrane domain called lipid rafts. The mature RSV particles assemble as filamentous projections called virus filaments, and these structures form on the surface of many permissive cell types indicating that this is a robust feature of the RSV particle assembly. The virus filaments also form on nasal airway organoids systems providing evidence that these structures also have a clinical relevance.
View Article and Find Full Text PDFCureus
December 2024
Department of Internal Medicine, Hiroshima City Funairi Citizens Hospital, Hiroshima, JPN.
Although human metapneumovirus(hMPV) infection can induce severe symptoms in older adults or immunocompromised patients, it usually causes mild symptoms in young immunocompetent adults. The prevalence of hMPV infectious disease is highest during the late winter and early summer. We report a hypoxemic case of hMPV infection in a young immunocompetent man that occurred in the first autumn after the reclassification of coronavirus disease (COVID-19) from Class 2 to Class 5.
View Article and Find Full Text PDFIJID Reg
March 2025
Postgraduate Program in Parasitic Biology, Federal University of Sergipe, Sergipe, Brazil.
Objectives: To investigate the prevalence of nine respiratory viruses and their clinical characteristics in children aged up to 5 years old in the state of Sergipe, Northeast of Brazil in the pre-COVID-19 pandemic period.
Methods: Children with suspected influenza virus infection were included in the study. Clinical samples were screened using real-time quantitative polymerase chain reaction for the diagnosis of adenovirus, parainfluenza (PIV)1, PIV2, PIV3, and human metapneumovirus.
Commun Biol
January 2025
School of Population Medicine and Public Health, Public Health Emergency Management Innovation Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Acute respiratory infections (ARI) with multiple types of viruses are common in infants and children. This study was conducted to assess the difference of oropharyngeal microbiome during acute respiratory viral infection using whole-genome shotgun metagenomic sequencing. The overall taxonomic alpha diversity did not differ by the types of infected virus.
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