Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ijcard.2003.10.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Glutamine Synthetase: Diverse Regulation and Functions of an Ancient Enzyme.
Biochemistry
January 2025
Department of Chemistry and Biochemistry, San Francisco State University, 1600 Holloway Avenue, San Francisco, California 94132, United States.
Glutamine synthetase (GS) is a ubiquitous enzyme central to nitrogen metabolism, catalyzing the ATP-dependent formation of glutamine from glutamate and ammonia. Positioned at the intersection of nitrogen metabolism with carbon metabolism, the activity of GS is subject to sophisticated regulation. While the intricate regulatory pathways that govern GS were established long ago, recent work has demonstrated that homologues are controlled by multiple distinct regulatory patterns, such as the metabolite induced oligomeric state formation in archaeal GS by 2-oxoglutarate.
View Article and Find Full Text PDFOrigami of KR-12 Designed Antimicrobial Peptides and Their Potential Applications.
Antibiotics (Basel)
August 2024
Department of Pathology, Microbiology, and Immunology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198, USA.
This review describes the discovery, structure, activity, engineered constructs, and applications of KR-12, the smallest antibacterial peptide of human cathelicidin LL-37, the production of which can be induced under sunlight or by vitamin D. It is a moonlighting peptide that shows both antimicrobial and immune-regulatory effects. Compared to LL-37, KR-12 is extremely appealing due to its small size, lack of toxicity, and narrow-spectrum antimicrobial activity.
View Article and Find Full Text PDFStaphylococcal aconitase expression during iron deficiency is controlled by an sRNA-driven feedforward loop and moonlighting activity.
Nucleic Acids Res
August 2024
Université Paris-Saclay, CEA, CNRS, Institute for Integrative Biology of the Cell (I2BC), 91198 Gif-sur-Yvette, France.
Article Synopsis
- Pathogenic bacteria like Staphylococcus aureus use regulatory RNA (sRNA) called IsrR to adapt to low iron conditions and maintain virulence.
- IsrR helps conserve iron by down-regulating genes for iron-containing enzymes, particularly affecting the tricarboxylic acid (TCA) cycle and the enzyme aconitase.
- Aconitase also acts as a regulatory protein that influences its own expression and modulates the expression of other enzymes, thereby helping the bacteria cope with iron scarcity.
Creation of an international laboratory network towards global microplastics monitoring harmonisation.
Sci Rep
June 2024
School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Infrastructure is often a limiting factor in microplastics research impacting the production of scientific outputs and monitoring data. International projects are therefore required to promote collaboration and development of national and regional scientific hubs. The Commonwealth Litter Programme and the Ocean Country Partnership Programme were developed to support Global South countries to take actions on plastics entering the oceans.
View Article and Find Full Text PDFEfficacy and safety of fezolinetant for moderate to severe vasomotor symptoms associated with menopause among women in East Asia: a phase 3 randomized study (MOONLIGHT I).
J Int Med Res
May 2024
Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College, Beijing.
Article Synopsis
- The study aimed to assess the effectiveness and safety of fezolinetant for treating moderate to severe vasomotor symptoms (VMS) in East Asian postmenopausal women.
- Conducted as a randomized, double-blind phase 3 trial, participants received either fezolinetant (30 mg/day) or a placebo over 12 weeks, followed by an open-label phase.
- Results showed no significant difference in VMS frequency or severity between fezolinetant and placebo, indicating that while fezolinetant was generally safe, it was not effective in reducing these symptoms.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!