Introduction: Hypertension is often undiagnosed, untreated, undertreated, and poorly controlled. Many patients use the emergency department as their primary source of health care, and the emergency department represents an opportunity to identify undiagnosed hypertension. We sought to (1) identify the prevalence of elevated blood pressures in low-acuity patients and (2) describe the existing practice of reassessment, treatment, and referral of abnormal vital signs in these patients.
Methods: We conducted a retrospective study of 88 ED patients at an academic medical center. All patients meeting Emergency Severity Index level 4 or 5 criteria (low acuity) were eligible. The following variables were recorded: triage level, medical history and medications, disposition, and all blood pressures. The investigators independently reviewed and reached consensus regarding the following outcome variables: the need for and actual treatment of elevated blood pressure, and the need for and referral for blood pressure recheck after discharge.
Results: Thirty-seven patients (45%) had hypertension by definition on arrival. Systolic hypertension was more common. Ten of the patients (27%) with elevated blood pressures had documented rechecks prior to discharge in the emergency department, and only one patient was referred for follow-up. Twenty-seven out of 37 low-acuity patients (73%) who presented with elevated blood pressures had no documentation of the blood pressure being rechecked and no documentation of the patient being referred.
Conclusion: Our data suggest that important opportunities for education and follow-up of hypertension are being missed.
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1st Internal Medicine Department, AHEPA University Hospital, School of Medicine, Aristotle University of Thessaloniki, 55436 Thessaloniki, Greece.
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Clinical and Translational Science Institute, University of Rochester, Rochester, NY 14642, USA.
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Department of Chemistry, University of Toronto, 80 St. George Street, Toronto, ON M5S 3H6, Canada.
Ovarian cancer (OC) must be detected in its early stages when the mortality rate is the lowest to provide patients with the best chance of survival. Lysophosphatidic acid (LPA) is a critical OC biomarker since its levels are elevated across all stages and increase with disease progression. This paper presents an LPA assay based on a thickness shear mode acoustic sensor with dissipation monitoring that involves a new thiol molecule 3-(2-mercaptoethanoxy)propanoic acid (HS-MEG-COOH).
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College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
Cyclovirobuxine D, a natural compound derived from the medicinal plant Buxus sinica, demonstrates a diverse array of therapeutic benefits, encompassing anti-arrhythmic properties, blood pressure regulation, neuronal protection, and anti-ischemic activity. However, its limited solubility hinders the bioavailability of current oral and injectable formulations, causing considerable adverse reactions and toxicity. In this investigation, we embarked on an unprecedented exploration of the skin penetration potential of cyclovirobuxine D utilizing chemical penetration enhancers and niosomes as innovative strategies to enhance its dermal absorption.
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Department of Obstetrics and Gynecology, Grigore T. Popa University of Medicine and Pharmacy, 700111 Iasi, Romania.
Diabetes is a widespread metabolic illness. Mismanagement of diabetes can lead to severe complications that tremendously impact patients' quality of life. The assimilation of nanotechnology in diabetes care holds the potential to revolutionize treatment paradigms, improve patient outcomes, and reduce the economic burden associated with this pervasive disease.
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