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Trends in antimicrobial susceptibility patterns of bacterial isolates in Lahore, Pakistan.
Front Antibiot
June 2023
Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Punjab, Pakistan.
Background: Antimicrobial resistance (AMR) has provoked a global health issue. Antimicrobial stewardship programs should be implemented to overcome this issue. The aim of this study was to determine the sensitivity patterns of the WHO Access, Watch, Reserve (AWaRe) group of antibiotics that assists in the selection of appropriate empiric antibiotic therapies.
View Article and Find Full Text PDFA comparison of various feature extraction and machine learning methods for antimicrobial resistance prediction in .
Front Antibiot
March 2023
Department of Biostatistics and Medical Informatics, School of Medicine, Acibadem Mehmet Ali Aydinlar University, Istanbul, Türkiye.
Streptococcus pneumoniae is one of the major concerns of clinicians and one of the global public health problems. This pathogen is associated with high morbidity and mortality rates and antimicrobial resistance (AMR). In the last few years, reduced genome sequencing costs have made it possible to explore more of the drug resistance of S.
View Article and Find Full Text PDFA whole-genome assay identifies four principal gene functions that confer tolerance of meropenem stress upon .
Front Antibiot
September 2022
Microbes in the Food Chain, Quadram Institute Bioscience, Norwich, United Kingdom.
We report here the identification of four gene functions of principal importance for the tolerance of meropenem stress in : cell division, cell envelope synthesis and maintenance, ATP metabolism, and transcription regulation. The primary mechanism of β-lactam antibiotics such as meropenem is inhibition of penicillin binding proteins, thus interfering with peptidoglycan crosslinking, weakening the cell envelope, and promoting cell lysis. However, recent systems biology approaches have revealed numerous downstream effects that are triggered by cell envelope damage and involve diverse cell processes.
View Article and Find Full Text PDFPoint prevalence survey to assess antibiotic prescribing pattern among hospitalized patients in a county referral hospital in Kenya.
Front Antibiot
October 2022
Directorate of Grant and Development, Mount Kenya University, Thika, Kenya.
Antibiotic resistance causes higher morbidity and mortality and higher healthcare costs. One of the factors influencing the emergence of antibiotic resistance is the inappropriate use of antibiotics. Clinical practitioners' incorrect prescription patterns and a disregard for antibiotic usage recommendations are the leading causes of this resistance.
View Article and Find Full Text PDFAntibiogram profiles of pathogenic and commensal bacteria in goat and sheep feces on smallholder farm.
Front Antibiot
May 2024
Department of Food and Animal Sciences, Tennessee State University, Nashville, TN, United States.
Introduction: The increase of antimicrobial resistance (AMR) in zoonotic pathogens poses a substantial threat to both animal production and human health. Although large-scale animal farms are acknowledged as major reservoirs for AMR, there is a notable knowledge gap concerning AMR in small-scale farms. This study seeks to address this gap by collecting and analyzing 137 fecal samples from goat and sheep farms in Tennessee and Georgia.
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