[Effect of lysozyme on the functional and metabolic activity of polymorphonuclear leukocytes in the acute blood loss].

Eksp Klin Farmakol

Department of Obstetrics and Gynecology, Kursk State Medical University, ul. K. Marksa 3, Kursk, 305033 Russia.

Published: August 2004

Acute hemorrhage leads to a decrease in the phagocyte number and index, the NBT test parameters, and the NADPH oxidase activity and to an increase in the Ca2+ ATPase activity in polymorphonuclear leukocytes on the peripheral blood. Lysozyme produces effective correction of the above parameters of the functional-metabolic activity of these cells. The drug effect is mediated by cytokines of splenocytes sticking to the glass.

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