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Clinical Potential of Novel Microbial Therapeutic LP51 Based on Xerosis-Microbiome Index.
Cells
December 2024
Human Microbiome Medical Center (HM·MRC), Soonchunhyang University, 22, Soonchunhyang-ro, Sinchang-myeon, Asan-si 31538, Chungnam, Republic of Korea.
Xerosis, characterized by dry, rough skin, causes discomfort and aesthetic concerns, necessitating effective treatment. Traditional treatments often show limited efficacy, prompting the need for innovative therapies. This study highlights the efficacy of microbiome therapeutic LP51, derived from a healthy vaginal microbiome, in improving xerosis.
View Article and Find Full Text PDFAmino acid metabolites profiling in unpredictable chronic mild stress-induced depressive rats and the protective effects of Gastrodia elata Blume and gastrodin.
J Ethnopharmacol
January 2025
Institute of Food Science and Technology, National Taiwan University, Taipei, Taiwan; Center for Food and Biomolecules, National Taiwan University, Taipei, Taiwan; National Center for Food Safety Education and Research, National Taiwan University, Taipei, Taiwan. Electronic address:
Article Synopsis
- - Major depressive disorder (MDD) affects around 350 million people globally, with studies indicating altered amino acids in blood as potential biomarkers for understanding depression.
- - The study aimed to explore how supplementing Gastrodia elata Blume (GEB) and its active compound gastrodin (GAS) might reverse these altered amino acid profiles in a model of depression using rats.
- - Findings revealed that GEB and GAS supplementation successfully reversed changes in key amino acids related to depressive-like behaviors in rats, suggesting their potential for alleviating depression and providing insights for future treatments.
Exposure of Colon-Derived Epithelial Monolayers to Fecal Luminal Factors from Patients with Colon Cancer and Ulcerative Colitis Results in Distinct Gene Expression Patterns.
Int J Mol Sci
September 2024
Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 405 30 Gothenburg, Sweden.
Microbiota and luminal components may affect epithelial integrity and thus participate in the pathophysiology of colon cancer (CC) and inflammatory bowel disease (IBD). Therefore, we aimed to determine the effects of fecal luminal factors derived from patients with CC and ulcerative colitis (UC) on the colonic epithelium using a standardized colon-derived two-dimensional epithelial monolayer. The complex primary human stem cell-derived intestinal epithelium model, termed RepliGut Planar, was expanded and passaged in a two-dimensional culture which underwent stimulation for 48 h with fecal supernatants (FS) from CC patients ( = 6), UC patients with active disease ( = 6), and healthy subjects (HS) ( = 6).
View Article and Find Full Text PDFDevelopment and evaluation of a model to identify publications on the clinical impact of pharmacist interventions.
Res Social Adm Pharm
December 2024
Department of Pharmacy, CHU Sainte-Justine, 3175 Côte-Sainte-Catherine, Montréal, Québec, Canada. Electronic address:
Background: Pharmacists are increasingly involved in patient care. Pharmacy practice research helps them identify the most clinically meaningful interventions. However, the lack of a widely accepted controlled vocabulary in this field hinders the discovery of this literature.
View Article and Find Full Text PDFAdiposity and cardiac autonomic function in children with a family history of obesity.
Clin Auton Res
December 2024
Department of Pediatrics, Université de Montréal, Montreal, QC, Canada.
Purpose: Data on associations between adiposity and heart rate variability (HRV) in prepubertal children are limited. We examined the associations between adiposity indices and HRV, independent of lifestyle behaviors, comparing multiple indicators of adiposity, and explored differences between boys and girls.
Methods: Data stem from 469 participants of the QUALITY cohort (630 children aged 8-10 years with a parental history of obesity).
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