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The Efficacy of the Charlson Comorbidity Index and Its Age-Adjusted Version in Forecasting Mortality and Postoperative Outcomes Following Isolated Coronary Artery Bypass Grafting.
J Clin Med
January 2025
Department of Cardiovascular Surgery, School of Medicine, Kocaeli University, 41001 Kocaeli, Turkey.
: The Charlson Comorbidity Index (CCI) is designed for evaluating comorbidities and mortality risks, with the age-adjusted CCI (ACCI) combining age and comorbidity assessments. Despite its long-standing use, research on CCI's application in cardiac surgery patients is limited. This study assessed the effectiveness of CCI and ACCI in predicting in-hospital mortality and post-surgery outcomes for patients undergoing isolated coronary artery bypass grafting (CABG).
View Article and Find Full Text PDFLow-dose quinine targets KCNH6 to potentiate glucose-induced insulin secretion.
J Mol Cell Biol
January 2025
Department of Endocrinology, Beijing Diabetes Institute, Beijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Insulin secretion is mainly regulated by two electrophysiological events, depolarization initiated by the closure of ATP-sensitive K+ (KATP) channels and repolarization mediated by K+ efflux. Quinine, a natural component commonly used for the treatment of malaria, has been reported to directly stimulate insulin release and lead to hypoglycemia in patients during treatment through inhibiting KATP channels. In this study, we verified the insulinotropic effect of quinine on the isolated mouse pancreatic islets.
View Article and Find Full Text PDF[Diagnosis and management of unilateral temporomandibular ankylosis].
Orthod Fr
January 2025
Service de Chirurgie maxillo-faciale, CHU de Caen Normandie, avenue de la Côte de Nacre, 14033 Caen, France
Introduction: Temporomandibular joint ankylosis is defined as permanent jaw constriction with an interincisal mouth opening of less than 30 mm, due to bony, fibro-osseous or fibrous fusion. Ankylosis may be uni- or bilateral. The complications of this ankylosis affect the functions of mastication, swallowing and phonation, sometimes facial morphology, and disturb dental hygiene.
View Article and Find Full Text PDFChest tube provocative clamping in patients having moderate or intense air leaks after lung resection to accelerate recovery.
J Thorac Dis
December 2024
Guangdong Lung Cancer Institute, Guangdong Provincial Key Laboratory of Translational Medicine in Lung Cancer, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, Guangzhou, China.
Background: Postoperative air leak is the most common complication after pulmonary resection. "Provocative clamping" was first described in 1992 in the context of guiding chest tube removal despite persistent air leak. However, early provocative clamping after pulmonary resection has not been evaluated.
View Article and Find Full Text PDFUltrafast multicellular calcium imaging of calcium spikes in mouse beta cells in tissue slices.
Acta Physiol (Oxf)
February 2025
Faculty of Medicine, University of Maribor, Maribor, Slovenia.
Background: The crucial steps in beta cell stimulus-secretion coupling upon stimulation with glucose are oscillatory changes in metabolism, membrane potential, intracellular calcium concentration, and exocytosis. The changes in membrane potential consist of bursts of spikes, with silent phases between them being dominated by membrane repolarization and absence of spikes. Assessing intra- and intercellular coupling at the multicellular level is possible with ever-increasing detail, but our current ability to simultaneously resolve spikes from many beta cells remains limited to double-impalement electrophysiological recordings.
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