A scheme enabling the acquisition of high-resolution nuclear magnetic resonance (NMR) spectra within inhomogeneous magnetic fields is introduced and exemplified. The scheme is based on the spatial encoding protocol recently introduced for collecting multidimensional NMR data within a single scan, which retrieves spectral information via interference phenomena between spin packets located at distinct positions within the sample. This in turn enables compensating for field inhomogeneities over the sample as a whole by shifting the phases of the radio-frequency pulses involved in the spatial encoding, rather than by demanding an extreme uniformity in the employed magnetic field. The upper tolerable field inhomogeneity limit thus becomes orders of magnitude higher than that in conventional time-domain acquisitions. No particular spatial dependencies are demanded by the new scheme, which can yield its high-resolution results on a single-scan basis.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1021/ja048859u | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, WI 53706.
Given the influence of cognitive abilities on life outcomes, there is inherent value in identifying genes involved in controlling learning and memory. Further, cognitive dysfunction is a core feature of many neuropsychiatric disorders. Here, we use a combinatory in silico approach to identify human gene targets that will have an especially high likelihood of individually and directly impacting cognition.
View Article and Find Full Text PDFiScience
January 2025
State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.
MT+ is pivotal in the dorsal visual stream, encoding tool-use characteristics such as motion speed and direction. Despite its conservation between humans and monkeys, differences in MT+ spatial location and organization may lead to divergent, yet unexplored, connectivity patterns and functional characteristics. Using diffusion tensor imaging, we examined the structural connectivity of MT+ subregions in macaques and humans.
View Article and Find Full Text PDFMed Biol Eng Comput
January 2025
Radiol Dept, Jiangnan Univ, Affiliated Hosp, Wuxi, 214122, Jiangsu, People's Republic of China.
In computer-aided diagnosis systems, precise feature extraction from CT scans of colorectal cancer using deep learning is essential for effective prognosis. However, existing convolutional neural networks struggle to capture long-range dependencies and contextual information, resulting in incomplete CT feature extraction. To address this, the PEDRA-EFB0 architecture integrates patch embeddings and a dual residual attention mechanism for enhanced feature extraction and survival prediction in colorectal cancer CT scans.
View Article and Find Full Text PDFSci Rep
January 2025
School of Computer and Information Technology, Xinyang Normal University, Xinyang, Henan Province, 464000, P. R. China.
Accurate detection of surface defects on strip steel is essential for ensuring strip steel product quality. Existing deep learning based detectors for strip steel surface defects typically strive to iteratively refine and integrate the coarse outputs of the backbone network, enhancing the models' ability to express defect characteristics. Attention mechanisms including spatial attention, channel attention and self-attention are among the most prevalent techniques for feature extraction and fusion.
View Article and Find Full Text PDFAm J Physiol Lung Cell Mol Physiol
January 2025
Department of Pharmacology and Toxicology, University of Utah College of Pharmacy, Salt Lake City, UT, USA.
Ozone (O) is a ubiquitous pollutant known to produce acute, transient inflammation through oxidative injury and inflammation. These effects are exacerbated in susceptible populations, such as the elderly and those exhibiting genetic mutations in central nodes of pulmonary function. To comprehend the impact of these predisposing factors, the present study examines structural, mechanical, and immunological responses to single acute O exposure (0.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!