Studer's ortothopic neobladder after radical cistectomy has become a good alternative and has improved the patients' quality of life. Voiding dysfunction after surgery is one of the possible late complications with incomplete emptying of the neobladder and chronical urinary retention. The mechanical obstruction may be due to recurrence of the tumor, anterior vaginal wall prolapse, urethrointestinal anastomosis stricture, mucose plug, stone and mucosal fold. We present a clinical case of voiding dysfunction after radical cystectomy with Studer's neobladder. One year after surgery the patient developed obstructive symptoms due to a mucosal fold of the neobladder. An endoscopic incision resolved the obstructive symptoms.
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Biopolymers
January 2025
Faculty of Pharmacy, Universiti Teknologi MARA, Selangor Branch, Puncak Alam Campus, Puncak Alam, Selangor, Malaysia.
This study aims to evaluate the impact of formulation parameters on tannic acid-crosslinked gelatine (GelTA) films, intended as a mucoadhesive matrix for extended buccal drug delivery. GelTA films were prepared using the solvent evaporation technique and screened based on their mucoadhesive and dissolution characteristics. The formulation variables included the source of gelatine (bovine and fish), tannic acid concentration, pH of the film-forming solutions, and the type and concentration of plasticisers.
View Article and Find Full Text PDFHeliyon
December 2024
Department of Industrial and Data Engineering, Hongik University, Seoul, South Korea.
Introduction: Laryngeal cancer diagnosis relies on specialist examinations, but non-invasive methods using voice data are emerging with artificial intelligence (AI) advancements. Mel Frequency Cepstral Coefficients (MFCCs) are widely used for voice analysis, but Octave Frequency Spectrum Energy (OFSE) may offer better accuracy in detecting subtle voice changes.
Problem Statement: Accurate early diagnosis of laryngeal cancer through voice data is challenging with current methods like MFCC.
Background: Pneumococcal conjugate vaccines (PCVs) that are ten-valent (PCV10) and 13-valent (PCV13) became available in 2010. We evaluated their global impact on invasive pneumococcal disease (IPD) incidence in all ages.
Methods: Serotype-specific IPD cases and population denominators were obtained directly from surveillance sites using PCV10 or PCV13 in their national immunisation programmes and with a primary series uptake of at least 50%.
Int J Biol Macromol
December 2024
Department of Pharmaceutics, Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.
The present study aims to develop a novel thiolated carboxymethyl cellulose (CMC-SH) by the addition of aldehyde groups via oxidation followed by reductive amination and then develop CMC-SH based pH-responsive hydrogel by free radical polymerization approach while assessing its mucoadhesive and permeation-enhancing capabilities. By in-vitro characterization, the intended compound's chemical composition, thermal stability, and amorphous nature were analyzed for CMC-SH polymer. Ellman's assay was utilized to estimate the thiol content and permeation analysis was performed to evaluate its enhanced permeability characteristics.
View Article and Find Full Text PDFGut
December 2024
Pediatric Gastroenterology, Cleveland Clinic, Cleveland, Ohio, USA.
Background: One in three children with Crohn's disease develop perianal fistula complications (PFCs), among the most disturbing and difficult-to-treat disease-related complications. Retrospective evidence suggests PFCs may be preventable.
Objective: We aimed to determine if early antitumour necrosis factor-alpha (anti-TNF⍺) therapy prevents PFC development in a well-characterised prospective cohort of paediatric patients with Crohn's disease who were free from PFC at enrolment.
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