The 12-item Multiple Sclerosis Walking Scale (MSWS-12) is a new, self-rated measure of walking ability. The scale has not been independently validated for use in differing MS populations. One hundred forty-nine patients in the community and 53 hospital outpatients with MS completed the MSWS-12 and other outcome measures. The psychometric properties of the MSWS-12 were excellent, and in particular the scale is responsive to change.
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http://dx.doi.org/10.1212/01.wnl.0000127604.84575.0d | DOI Listing |
Rheumatology (Oxford)
January 2025
Department of Cell Biology and Immunology, Institute of Parasitology and Biomedicine López-Neyra, CSIC, Granada, Spain.
Objectives: COVID-19 and systemic sclerosis (SSc) share multiple similarities in their clinical manifestations, alterations in immune response, and therapeutic options. These resemblances have also been identified in other immune-mediated inflammatory diseases where a common genetic component has been found. Thus, we decided to evaluate for the first time this shared genetic architecture with SSc.
View Article and Find Full Text PDFLaeknabladid
February 2025
Department of Neurology, University Hospital of Iceland, Reykjavik, Iceland.
Trigeminal neuralgia is the most common cause of facial pain in individuals over 50 years old and can have a profoundly negative impact on quality of life. Epidemiological studies have measured the annual incidence of trigeminal neuralgia at around 4-5 cases per 100,000 inhabitants per year. In Iceland, this would amount to about 16-20 new cases annually.
View Article and Find Full Text PDFJ Nat Prod
January 2025
Department of Pharmacognosy and Pharmaceutical Botany, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand.
Bibenzyls and dihydrophenanthrenes exhibit promising immunomodulatory effects in various human diseases. In this study, we isolated one new dihydrophenanthrene derivative (), two new bibenzyl-dihydrophenanthrene derivatives () along with 12 known compounds (-) from the methanol extract of . These compounds were identified by using physicochemical analyses and spectroscopic methods.
View Article and Find Full Text PDFNeuropsychiatr Dis Treat
January 2025
Department of Rehabilitation Medicine, The Affiliated Taian City Central Hospital of Qingdao University, Taian, 271000, People's Republic of China.
As the aging process accelerates and living conditions improve, central nervous system (CNS) diseases have become a major public health problem. Diseases of the CNS cause not only gray matter damage, which is primarily characterized by the loss of neurons, but also white matter damage. However, most previous studies have focused on grey matter injury (GMI), with fewer studies on white matter injury (WMI).
View Article and Find Full Text PDFIDCases
January 2025
Department of Infectious Diseases, Osaka City General Hospital, Osaka, Japan.
A 65-year-old woman with Multiple Sclerosis treated with fingolimod developed headaches and convulsions. Cerebrospinal fluid (CSF) culture indicated . A literature review of 20 cases of cryptococcal meningitis indicated that headache was the most common initial symptom, and all cases were positive for serum and/or CSF cryptococcal antigens.
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