The term computer aided orthopedic surgery (CAOS) stands for approaches that aim to improve visibility to the surgical field and increase application accuracy by means of so-called navigation systems alone or in combination with smart end-effectors when carrying out surgical actions. These goals achieved by linking the bony anatomy being operated on with a virtual representation, such as an image dataset. This article introduces the basic principles of CAOS. Surgical navigation systems that use modern tracking technology are introduced and classified according to the chosen virtual representation of the surgical object, ie, image-free and image-based (preoperative and intraoperative) technology. Within the latter class in particular, CT-and fluoroscopy-based (2-D and 3-D) systems have successfully made their way into the operating room (OR). Challenges during the development of the underlying enabling technologies are presented and references to orthopedic applications in different anatomical areas are given.
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http://dx.doi.org/10.1016/j.injury.2004.05.005 | DOI Listing |
BMC Oral Health
January 2025
Pediatric Dentistry and Dental Public Health, Faculty of Dentistry, Cairo University, Cairo, Egypt.
Introduction: Artificial intelligence (AI) applications have increased dramatically across a wide range of domains. Dental students will undoubtedly be impacted by the emergence of AI in dentistry.
Aim: This study aimed to evaluate the knowledge, attitudes, and perceptions of a group of Egyptian dental students toward artificial intelligence.
Pediatr Res
January 2025
Center for Genetic Medicine, Children's National Research Institute, Washington, DC, USA.
Background: Prenatally transmitted viruses can cause severe damage to the developing brain. There is unexplained variability in prenatal brain injury and postnatal neurodevelopmental outcomes, suggesting disease modifiers. Of note, prenatal Zika infection can cause a spectrum of neurodevelopmental disorders, including congenital Zika syndrome.
View Article and Find Full Text PDFNat Commun
January 2025
Institute of Molecular Physiology, Shenzhen Bay Laboratory, Shenzhen, 518132, China.
Nucleosome is the basic structural unit of the genome. During processes like DNA replication and gene transcription, the conformation of nucleosomes undergoes dynamic changes, including DNA unwrapping and rewrapping, as well as histone disassembly and assembly. However, the wrapping characteristics of nucleosomes across the entire genome, including region-specificity and their correlation with higher-order chromatin organization, remains to be studied.
View Article and Find Full Text PDFJ Neurointerv Surg
January 2025
Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
Neurointervention has seen significant advancements in recent decades with the adoption of myriad new technologies and techniques. Initially reliant on case reports and small case series, we now benefit from multicenter studies and randomized trials that can provide robust practice-changing evidencea and often employ sophisticated statistical methods. This two-part series on statistical principles in neurointervention aims to equip neurointerventionalists with essential statistical knowledge for critically reviewing literature and conducting methodologically sound research.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
University of Arizona, Tucson, AZ, USA.
Background: Age, sex, and APOE genotype are well-established risk factors for late-onset Alzheimer's Disease (LOAD). Previous findings demonstrate that neuroinflammatory profiles of the human midlife female brain closely resemble the human AD brain. Given APOE's role in LOAD pathogenesis, here we investigate the contribution of this risk factor on targeted AD relevant transcriptional pathways.
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