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The Aging Males' Symptoms scale (AMS) as outcome measure for treatment of androgen deficiency. | LitMetric

AI Article Synopsis

  • A study in Germany focused on testosterone treatment for 1174 androgen-deficient men to assess changes in symptoms using the AMS scale after 12 weeks of therapy.
  • Results indicated an average 32% improvement in symptoms, with varying degrees of improvement based on the severity of symptoms prior to treatment.
  • The AMS scale was effective in measuring quality of life improvements and could predict physicians' assessments of treatment effectiveness, offering a notable positive predictive value of 89%.

Article Abstract

Introduction: No clinical study data in which the AMS scale was applied as outcome measure has been reported until today.

Method: An open post-marketing study was performed by office-based urologists in Germany in 2000/01. We analysed data of 1174 androgen-deficient males who were treated with testosterone enanthate. The AMS scale was applied prior to and after 12 weeks treatment.

Results: The improvement of complaints during treatment relative to the baseline score was 32% on average. Patients with little or no symptoms before therapy improved by 11%, those with mild complaints at entry by 24%, with moderate by 31%, and with severe symptoms by 39% compared with the baseline score. We showed that the distribution of complaints of testosterone-deficient men before therapy almost returned to norm values after 12 weeks of testosterone treatment. We also demonstrated that the AMS results can predict the independent (physician's) opinion about the individual treatment effect. The positive predictive value was 89%, the negative predictive value 59%, sensitivity (correct prediction of a positive assessment by the urologist) 96%, however, the specificity (correct prediction of a negative assessment by the physician) was only 30%.

Conclusion: The AMS scale showed a convincing ability to measure treatment effects on quality of life across the full range of severity of complaints. In addition, results of the scale can predict the subjective clinical expert opinion on the treatment efficiency.

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Source
http://dx.doi.org/10.1016/j.eururo.2004.01.009DOI Listing

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