AI Article Synopsis
- The prefrontal cortex is crucial for long-term recognition memory, with specific neurons responding to familiar stimuli even after 24 hours.
- Neuronal responses indicating familiarity were mostly found in specific areas: ventromedial, orbitofrontal, and anterior cingulate, but not in the dorsolateral prefrontal cortex.
- The timing of neuron responses suggests that prefrontal activity starts after inferior temporal cortex processing, indicating its role in retrieving familiar information.
Article Abstract
Much evidence indicates that prefrontal cortex plays an important role in long-term recognition memory processes. Here, we report primate prefrontal neuronal responses carrying information necessary for long-term visual recognition memory. The responses of many neurons signaled stimulus familiarity even when the period over which stimuli had to be remembered extended to 24 hr. Such responses occurred frequently in ventromedial, orbitofrontal, and anterior cingulate but not dorsolateral prefrontal cortex. Prefrontal information processing, as indicated by the response latencies, started after that in inferior temporal cortex and might be related to retrieval processes, as responses were typically larger for familiar than for novel stimuli.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.neuron.2004.05.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Sex Affects Cognitive Outcomes in HIV-1 Tat Transgenic Mice: Role of CCR5.
ASN Neuro
January 2025
Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, Virginia, USA.
People living with HIV (PLWH) experience HIV-associated neurocognitive disorders (HAND), even though combination antiretroviral therapy (cART) suppresses HIV replication. HIV-1 transactivator of transcription (HIV-1 Tat) contributes to the development of HAND through neuroinflammatory and neurotoxic mechanisms. C-C chemokine 5 receptor (CCR5) is important in immune cell targeting and is a co-receptor for HIV viral entry into CD4+ cells.
View Article and Find Full Text PDFModulation pattern recognition method of wireless communication automatic system based on IABLN algorithm in intelligent system.
PLoS One
January 2025
School of Resources and Environment, Inner Mongolia University of Technology, Hohhot, China.
The aim of this study is to address the limitations of convolutional networks in recognizing modulation patterns. These networks are unable to utilize temporal information effectively for feature extraction and modulation pattern recognition, resulting in inefficient modulation pattern recognition. To address this issue, a signal modulation recognition method based on a two-way interactive temporal attention network algorithm has been developed.
View Article and Find Full Text PDFEffect of exogenous β-hydroxybutyrate on BDNF signalling, cognition, and amyloid precursor protein processing in humans with T2D and insulin resistant rodents.
Am J Physiol Cell Physiol
January 2025
School of Health and Exercise Sciences, The University of British Columbia, Okanagan,BC V1V 1V7, Canada.
People with type 2 diabetes (T2D) have a greater risk of developing neurodegenerative diseases, like Alzheimer's disease, in later life. Exogenous ketone supplements containing the ketone body β-hydroxybutyrate (β-OHB) may be a strategy to protect the brain as β-OHB can support cerebral metabolism and promote neuronal plasticity via expression of brain-derived neurotrophic factor (BDNF). Parallel human (ClinicalTrials.
View Article and Find Full Text PDFDevelopmental invariance in deep distortions.
Psychol Aging
January 2025
Department of Psychology, Trinity University.
Recently, a distinction has been drawn between conventional false memories, which misrepresent specific facts, and deep distortions, which misrepresent relations that connect facts. We report the first study of adult developmental trends in deep distortions, using a paradigm in which people make conjoint recognition judgments about incompatible facts (e.g.
View Article and Find Full Text PDFUnderstanding ICU Nursing Knowledge, Perceived Barriers, and Facilitators of Sepsis Recognition and Management: A Cross-Sectional Study.
Crit Care Explor
January 2025
Department of Critical Care Medicine, Alberta Health Services, AB, Canada.
Importance: Nursing workforce changes, knowledge translation gaps, and environmental/organizational barriers may impact sepsis recognition and management within the ICU.
Objectives: To: 1) evaluate current ICU nursing knowledge of sepsis recognition and management, 2) explore individual and environmental or organizational factors impacting nursing recognition and management of sepsis using the Theoretical Domains Framework (TDF), and 3) describe perceived barriers and facilitators to nursing recognition and management of patients with sepsis.
Design, Setting, And Participants: This cross-sectional survey was administered to nurses working in four general system ICUs between October 24, 2023, and January 30, 2024.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!