Objective: To evaluate the spectrum of ST-T-wave patterns in Chinese patients with hereditary long-QT syndrome.
Methods: ECGs of 61 families were studied to determine ST-T-wave patterns. Genotypes were identified by sequencing.
Results: 32 cases showed similarity to LQT1, 41 to LQT2 and 2 to LQT3 in ECG, and 3 cases could not be classified. QTc of the patients with symptom was (0.547 +/- 0.08) sec and that of the patients without symptoms was (0.526 +/- 0.06) sec, both were much longer than that of normal members of the families. T wave patterns were different in 48 cases at different time. QTc difference in a same person between two times or DeltaQTc were as follows: (0.048 +/- 0.057) sec in patients and (0.023 +/- 0.017) sec in normal members (P < 0.001). 12 cases of LQT1 and 11 cases of LQT2 were identified by genotype sequencing.
Conclusions: There are some differences in ST-T waves between these Chinese hereditary long-QT syndrome patients and European and American patterns. These patients showed greater variability in ST-T wave pattern including the changes in the same type, in the same pedigree and in the same patients at different time.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Long QT Syndrome: LQT3 Variant Presenting in a Bradycardic Newborn.
Cureus
December 2024
Pediatric Cardiology, Centro Hospitalar Lisboa Central, Unidade Local de Saúde de São José, Lisbon, PRT.
Long QT Syndrome (LQTS) is a rare hereditary canalopathy, characterized by prolonged ventricular repolarization, which can lead to malignant tachyarrhythmias at a young age. Treatment typically involves healthy lifestyle changes and β-blocker therapy. In specific cases, the implantation of an implantable cardioverter defibrillator (ICD) can be an option.
View Article and Find Full Text PDFContribution of continuous intravenous lidocaine in managing congenital long QT syndrome with 2:1 atrioventricular block.
Indian Pacing Electrophysiol J
December 2024
National Institute of Cardiovascular Diseases, Pakistan. Electronic address:
Congenital long QT syndrome (LQTS) is a rare hereditary cardiac disorder characterized by prolongation of the QT interval on electrocardiogram (ECG), predisposing affected individuals to life-threatening arrhythmias. We present a case of a newborn with congenital LQTS and 2:1 atrioventricular (AV) block who presented with bradycardia and QT prolongation. Continuous intravenous lidocaine infusion was initiated, because of hypoglycemia with beta-blockers, resulting in stabilization of AV conduction and prevention of malignant arrhythmias.
View Article and Find Full Text PDFDofetilide unmasks long QT in a patient presenting with atrial fibrillation-induced cardiomyopathy.
HeartRhythm Case Rep
October 2024
Kansas City Heart Rhythm Institute, Overland Park, Kansas.
Computational insights into the mechanisms underlying structural destabilization and recovery in trafficking-deficient hERG mutants.
Front Mol Biosci
August 2024
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada.
Article Synopsis
- Cardiovascular diseases, particularly hereditary Long QT Syndrome (LQTS), are linked to ion channel dysfunctions, leading to a higher risk of sudden cardiac death, especially with the LQT2 type caused by mutations in the hERG gene.
- Specific high-affinity hERG blockers like E-4031 could potentially rescue these dysfunctional channels, but the mechanisms behind their effectiveness are unclear.
- The study employs accelerated molecular dynamics simulations to show how mutations in the hERG channel alter its structure and trafficking, and suggests that E-4031 may inhibit these detrimental changes, paving the way for new treatments targeting the underlying cellular issues.
Generation of a human induced pluripotent stem cell line ZZUNEUi030-A from a female patient carrying a heterozygous CALM2 (c.395 A > T) mutation.
Stem Cell Res
December 2024
Centre for Cardiovascular Diseases, Henan Key Laboratory of Hereditary Cardiovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou 450052, China. Electronic address:
Calmodulin mutations can cause life-threatening long QT syndrome involving CALM1, CALM2, and CALM3. In this study, human induced pluripotent stem cells ZZUNEUi030-A were derived from a female patient with heterozygous CALM2 gene c. 395A → T by Sendai virus non-integrated reprogramming technology.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!