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Effect of PENN-DIABEX, a novel polyherbal formulation, in high fat diet streptozotocin-induced diabetic rats.
Saudi J Biol Sci
November 2023
Department of Zoology, Faculty of Life Sciences, Government College University Faisalabad, 38000 Faisalabad, Pakistan.
Diabetes, a chronic metabolic disorder affecting millions worldwide, presents a significant health challenge characterized by impaired glucose regulation and potential complications. This study examines the antidiabetic effects of a polyherbal formulation (PENN-DIABEX) prepared from five different medicinal plant extracts. The objective is to ascertain its efficacy in managing streptozotocin (STZ) induced diabetes in rats.
View Article and Find Full Text PDFIdentifying potential therapeutic targets of mulberry leaf extract for the treatment of type 2 diabetes: a TMT-based quantitative proteomic analysis.
BMC Complement Med Ther
September 2023
Beijing Research Institute of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, 100029, China.
Background: Mulberry (Morus alba L.) leaf, as a medicinal and food homologous traditional Chinese medicine, has a clear therapeutic effect on type 2 diabetes mellitus (T2DM), yet its underlying mechanisms have not been totally clarified. The study aimed to explore the mechanism of mulberry leaf in the treatment of T2DM through tandem mass tag (TMT)-based quantitative proteomics analysis of skeletal muscle.
View Article and Find Full Text PDFEncapsulation and Assessment of Antidiabetic Potential of α-Lactalbumin-Derived Hydrolysates.
J Agric Food Chem
April 2023
Animal Physiology Division, National Dairy Research Institute, Karnal, Haryana 132001, India.
Dipeptidyl peptidase-IV (DPP-IV) is an exopeptidase mainly present in epithelial tissues of the liver, kidney, and intestine. It is involved in the cleavage of a variety of substrates including the incretin hormones like glucagon-like peptide-1 (GLP-1). GLP-1 binds to the GLP-1 receptors of pancreatic β-cells and leads to β-cell proliferation and increases insulin secretion through associated gene expression.
View Article and Find Full Text PDFEfficacy of Polydeoxyribonucleotide in Promoting the Healing of Diabetic Wounds in a Murine Model of Streptozotocin-Induced Diabetes: A Pilot Experiment.
Int J Mol Sci
January 2023
Department of Plastic and Reconstructive Surgery, Inje University Haeundae Paik Hospital, College of Medicine, Inje University, Busan 48108, Republic of Korea.
We assessed the efficacy of polydeoxyribonucleotide (PDRN) in accelerating the healing of diabetic wounds in a murine model of streptozotocin (STZ)-induced diabetes. After the creation of diabetic wounds, the mice of the PDRN SC, PDRN IP and PBS groups received a subcutaneous, an intra-peritoneal injection of PDRN and a subcutaneous injection of PBS, respectively. After euthanasia, time-dependent changes in the wound diameter and histologic scores were measured and vascular endothelial growth factor (VEGF), transforming growth factor-β1 (TGF-β1) and collagen types I and III were assessed for their expression levels.
View Article and Find Full Text PDFProtective Effect of Seed Extract and its Bioactive Compound Thymoquinone on Streptozotocin-induced Diabetic Rats.
Cardiovasc Hematol Agents Med Chem
January 2023
Biotechnology and Pharmacology Laboratory, Centre for Scientific Research and Development, People's, Jazan University, Bhopal, India.
Background: The lack of a substantial breakthrough in the treatment of diabetes, a global issue, has led to an ongoing quest for herbs that contain bioactive elements with hypoglycemic properties.
Objective: To investigate the potential protective effect of seeds ethanol extract and its active ingredient, thymoquinone, on streptozotocin-induced diabetic rats.
Methods: To induce diabetes, the male Wistar rats were administered an intraperitoneal injection of STZ at a dosage of 90 mg/kg body weight in 0.
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