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Dihydromyricetin reverses capecitabine-induced peripheral myelin dysfunction through modulation of oxidative stress.
Clin Exp Pharmacol Physiol
March 2024
Zhuji People's Hospital of Zhejiang Province, Shaoxin, China.
Previous clinical reports have shown that capecitabine, an oral prodrug of 5-fluorouracil (5-Fu), can induce peripheral neuropathy, resulting in numbness, paresthesia and hypoesthesia. However, the mechanism through which capecitabine causes peripheral nerve injury remains unclear. Here, we demonstrate that systemic administration of capecitabine leads to myelin abnormalities in the peripheral nerves of mice, which are possibly attributed to the death of Schwann cells, the myelinating cells in the peripheral nervous system.
View Article and Find Full Text PDFP38 MAPK, NF-κB, and JAK-STAT3 Signaling Pathways Involved in Capecitabine-Induced Hand-Foot Syndrome via Interleukin 6 or Interleukin 8 Abnormal Expression.
Chem Res Toxicol
March 2022
Zhejiang Provincial Key Laboratory for Drug Clinical Research and Evaluation, Department of Clinical Pharmacy, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 QingChun Road, Hangzhou, Zhejiang 310000, People's Republic of China.
Hand-foot syndrome (HFS) is a major adverse reaction to capecitabine (CAP). The exact pathogenesis of this disease remains unclear. In this study, metabolomics combined with cell RNA sequencing was used to study the mechanisms of CAP-induced HFS.
View Article and Find Full Text PDFCase Report: Various Abnormalities in Lipid and Glucose Metabolism Induced by Capecitabine.
Front Oncol
May 2021
Department of Diabetes, Endocrinology and Metabolism, Kawasaki Medical School, Kurashiki, Japan.
Capecitabine has been used for the treatment of various types of tumors. The rare side effects induced by capecitabine have been reported as hypertriglyceridemia, acute pancreatitis associated with hypertriglyceridemia and hypertriglyceridemia complicated with hyperglycemia. The mechanisms of capecitabine-induced hypertriglyceridemia are unclear.
View Article and Find Full Text PDFCapecitabine-Induced Takotsubo Cardiomyopathy: A Case Report.
Perm J
July 2020
Department of Cardiology, Baystate Medical Center, Springfield, MA.
Introduction: The medication 5-fluorouracil is known to cause cardiotoxic effects (with an incidence ranging from 5% to 18%), such as rhythm abnormalities and cardiomyopathies, including takotsubo cardiomyopathy. Capecitabine, an oral prodrug of 5-fluorouracil, has rarely been reported to cause cardiotoxic effects compared with its parent drug.
Case Presentation: An 80-year-old woman presented to the hospital with chest pain after recent initiation of capecitabine use for anal cancer.
Hyperammonemia after capecitabine associated with occult impairment of the urea cycle.
Cancer Med
May 2019
Department of Biochemistry, Stanford University, Stanford, California.
Background: Cancer patients receiving chemotherapy often complain of "chemobrain" or cognitive impairment, but mechanisms remain elusive.
Methods: A patient with gastric cancer developed delirium and hyperammonemia after chemotherapy with the 5-fluorouracil pro-drug capecitabine. Exome sequencing facilitated a search for mutations among 43 genes associated with hyperammonemia and affecting the urea cycle directly or indirectly.
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