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Exploring child and youth understanding of loneliness through qualitative insights and evaluating loneliness measures considering those lived experiences.
Ann N Y Acad Sci
January 2025
Wolfson Centre for Population Health, Queen Mary University of London, London, UK.
The overall goal of this paper is to enhance the understanding and measurement of loneliness by identifying key experiential characteristics of loneliness in children and adolescents, and determine whether there is a need for refined assessment tools that accurately capture that experience. In Study 1, we synthesized the qualitative research on the child and youth experience of loneliness and found shared characteristics of loneliness, with some differences related to developmental changes (e.g.
View Article and Find Full Text PDFHow children and adolescents with chronic pain describe their pain experiences: A qualitative systematic review.
Patient Educ Couns
January 2025
School of Primary and Allied Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, 47-49 Moorooduc Highway, Frankston, Victoria, Australia.
Purpose: To explore how children and adolescents with chronic pain describe their pain experiences.
Method: A systematic search of OVID Medline, CINAHL Complete, OVID Embase and APA PsycINFO (database inception to 19th August 2024) was conducted for qualitative or mixed-method studies investigating children's chronic pain experiences. Studies were excluded if focused on post-surgical or acute pain.
Initial clinical experience with [Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer: dosimetry, safety, and efficacy from the lead-in cohort of the SPLASH trial.
Front Oncol
January 2025
Department of Clinical Development, POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company, Indianapolis, IN, United States.
Introduction: SPLASH (NCT04647526) is a multicenter phase III trial evaluating the efficacy and safety of [Lu]Lu-PNT2002 radioligand therapy in metastatic castration-resistant prostate cancer (mCRPC). This study leveraged a lead-in phase to assess tissue dosimetry and evaluate preliminary safety and efficacy, prior to expansion into a randomized phase. Here we report those results.
View Article and Find Full Text PDFDevelopment of TAR-200: A novel targeted releasing system designed to provide sustained delivery of gemcitabine for patients with bladder cancer.
Urol Oncol
January 2025
Vita-Salute San Raffaele University and IRCCS San Raffaele Hospital, Milan, Italy; Department of Medical Oncology, IRCCS San Raffaele University, Milan, Italy.
Treatment options for recurrent high-risk non-muscle-invasive bladder cancer (HR NMIBC) and muscle-invasive bladder cancer (MIBC) are limited, highlighting a need for clinically effective, accessible, and better-tolerated alternatives. In this review we examine the clinical development program of TAR-200, a novel targeted releasing system designed to provide sustained intravesical delivery of gemcitabine to address the needs of patients with NMIBC and of those with MIBC. We describe the concept and design of TAR-200 and the clinical development of this gemcitabine intravesical system in the SunRISe portfolio of studies.
View Article and Find Full Text PDFBiopriming of Maize with their endophyte Aspergillus fumigatus reinforces their resistance to salinity stress and improves their physiological traits.
BMC Plant Biol
December 2024
Botany and Microbiology Department, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt.
Zea mays L. (Maize) is one of the most crucial world's crops, for their nutritional values, however, the water scarcity and consequent soil salinization are the major challenges that limit the growth and productivity of this plant, particularly in the semi-arid regions in Egypt. Recently, biopriming has been recognized as one of the most efficient natural-ecofriendly approaches to mitigate the abiotic salt stress on plants.
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