Structurally modified 3-(N-benzylamino)propylphosphonic acid S1P receptor agonists that maintain affinity for S1P1, and have decreased affinity for S1P3 are efficacious, but exhibit decreased acute cardiovascular toxicity in rodents than do nonselective agonists.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2004.04.070 | DOI Listing |
Publication Analysis
Top Keywords
acute cardiovascular
8
3-n-benzylaminopropylphosphonic acid
8
acid s1p
8
s1p receptor
8
receptor agonists
8
selecting s1p3
4
s1p3 enhances
4
enhances acute
4
cardiovascular tolerability
4
tolerability 3-n-benzylaminopropylphosphonic
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!