[reaction: see text] The regioselective functionalization of 4,12-dibromoparacyclophane via electrophilic aromatic substitution is reported for the first time. The functionalization of the paracyclophane backbone allows the development of a new family of paracyclophane-based phosphines (named ParaPhos) that opens the possibility of improved catalyst development and tuning while retaining all the catalysis potential of the PhanePhos family of ligands.
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| http://dx.doi.org/10.1021/ol049509f | DOI Listing |
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