AI Article Synopsis
- Blood monocytes produce various bioactive substances essential for regulating inflammatory responses.
- Recent research indicates that IL-7, a cytokine that activates T and B cells, enhances the expression of monocyte-derived proinflammatory cytokines, particularly IL-8.
- The study demonstrates that IL-7 directly promotes IL-8 production from monocytes, independent of new protein synthesis, and amplifies IL-8 production in response to other inflammatory stimuli like LPS, TNF, and IL-1.
Article Abstract
Blood monocytes are important cellular sources of a vast array of bioactive substances, including regulatory and chemotactic cytokines. The regulation of these cytokines is of critical importance to the expression of acute and chronic inflammatory responses. IL-7, a T and B cell-activating cytokine, has recently been shown to have stimulatory effects on the expression of several monocyte-derived proinflammatory cytokines. We now describe the induction of IL-8 mRNA and extracellular protein from human blood monocytes by IL-7. The up-regulation of IL-8 mRNA by IL-7 was not altered by concomitant treatment with cycloheximide, suggesting that the direct stimulatory effects of IL-7 were not dependent upon de novo protein synthesis. In addition, IL-7 significantly potentiated the production of IL-8 from LPS-, TNF-, and IL-1-treated peripheral blood monocytes. Our findings suggest that IL-7 may play a critical role in the modulation of macrophage-derived cytokine expression and may function in vivo as an important proinflammatory cytokine.
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