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[Celiac disease: an update].
Inn Med (Heidelb)
January 2025
Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital, LMU Klinikum München, München, Deutschland.
Celiac disease is one of the most common lifelong autoimmune disorders and is currently understood as a genetically determined immune intolerance to gluten. In genetically predisposed individuals, the consumption of gluten, along with additional environmental factors, triggers an immunological reaction in the small intestinal epithelium, leading to the destruction of the mucosal architecture with villous atrophy. This can be asymptomatic, but may also cause a wide range of symptoms and lead to systemic complications, such as osteoporosis or infertility.
View Article and Find Full Text PDFImproving cefazolin administration for surgical prophylaxis in reported penicillin allergy: A retrospective study of a health system intervention.
J Allergy Clin Immunol Glob
February 2025
Section of Rheumatology, Allergy, and Immunology, Department of Internal Medicine, Yale School of Medicine, New Haven, Conn.
Background: Cefazolin is the most common first-line antibiotic to prevent surgical-site infections. Patients with penicillin allergy labels often receive alternative antibiotics, which is associated with increased rates of surgical-site infections, multi-drug-resistant infections, and cost.
Objective: We sought to determine whether a hospital-wide guideline recommending first-line surgical prophylaxis in patients with penicillin allergy labels can increase the use of cefazolin without compromising safety.
Reforming the innovation system to deliver affordable medicines: a conceptual framework of pharmaceutical innovation as a complex adaptive system (forest) and theory of change.
J Pharm Policy Pract
January 2025
Global Health Centre, Graduate Institute of International and Development Studies, Geneva, Switzerland.
Background: The current mainstream pharmaceutical innovation system (PIS) is driven by the market-based logic of charging the highest prices societies will bear. Outcomes include unaffordable medicines, restricted access and pressure on health budgets. How can the innovation system change to deliver fairly-priced medicines?
Methods: We inductively developed a novel conceptual framework of the PIS as a complex adaptive system (CAS) analogous to a forest.
Trichomoniasis, caused by the parasite , is the most common non-viral sexually transmitted infection. Current treatment relies exclusively on 5-nitroimidazole drugs, with metronidazole (MTZ) as the primary option. However, the increasing prevalence of MTZ-resistant strains poses a significant challenge, particularly in the current absence of alternative therapies.
View Article and Find Full Text PDFDetermination of main lipids and volatile compounds in unconventional cold-pressed seed oils through chromatographic techniques.
J Food Sci
January 2025
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, Messina Institute of Technology, University of Messina, Messina, Italy.
The purpose of this study was to characterize unconventional cold-pressed seed oils (rosehip, strawberry, blackcurrant, carrot, plum, pomegranate, radish, and raspberry) as novel alternative edible oil source. A chemical characterization of different lipid components (total fatty acid composition, triacylglycerols, and vitamin E) and volatiles responsible for the particular aroma of these oils was reported. All the oils showed a content of unsaturated fatty acids, mainly oleic, linoleic, and α-linolenic acid, that potentially contribute to the prevention of cardiovascular diseases, in the range of 80%-90%.
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