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Xiaohuafuning tang intervenes liver-depression-and-spleen-deficiency syndrome chronic-atrophic-gastritis by reshaping amino acid metabolism through gut Microbiota.
Phytomedicine
January 2025
Institue of Pharmaceutical Department, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, No 117, Meishan Road, Hefei 230031, Anhui, PR China. Electronic address:
Background: Xiaohua Funing Tang (XHFND) is a decoction formula of traditional Chinese medicine (TCM) and possesses the potential to manage chronic atrophic gastritis (CAG) with liver depression and spleen deficiency (LDSD), but the mechanisms were still unclear.
Purpose: Our aim is to reveal the overall synergistic mechanisms of XHFND against CAG with LDSD.
Methods: Based on a CAG rat model with LDSD, this study combined metabolomics, gut microbiota, and network pharmacology techniques to demonstrate the XHFND mechanisms with multiple components and targets.
Preventative treatment of tuberous sclerosis complex with sirolimus: Phase I safety and efficacy results.
Ann Child Neurol Soc
June 2024
Division of Neurology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Objective: Tuberous sclerosis complex (TSC) results from overactivity of the mechanistic target of rapamycin (mTOR). Sirolimus and everolimus are mTOR inhibitors that treat most facets of TSC but are understudied in infants. We sought to understand the safety and potential efficacy of preventative sirolimus in infants with TSC.
View Article and Find Full Text PDFCRISPR-Cas9-Mediated Correction of Pathogenic Variants in iPSCs from Patients with Tuberous Sclerosis Complex Type 2.
CRISPR J
December 2024
The Steve and Cindy Rasmussen Institute for Genomic Medicine, Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder caused by mutations in either the or genes. Though TSC causes the formation of nonmalignant tumors throughout multiple organs, the most frequent causes of mortality and morbidity are due to neurological complications. In two-thirds of cases, TSC occurs sporadically and pathogenic variants are approximately three times more prevalent than pathogenic variants.
View Article and Find Full Text PDFDiagnostic flow analysis of tuberous sclerosis complex in Japan: a retrospective claims database study.
Orphanet J Rare Dis
December 2024
Department of Urology, Seirei Yokohama Hospital, Yokohama, Japan.
Article Synopsis
- Tuberous sclerosis complex (TSC) is a genetic disorder difficult to diagnose due to non-specific symptoms, leading to a study investigating the time to diagnosis (TTD) among Japanese patients.
- The research analyzed data from 2005 to 2020, dividing patients into two cohorts based on age at diagnosis, and assessed the TTD and incidence of TSC-related and unrelated symptoms.
- Findings showed that those with renal tumors experienced significant delays in diagnosis and that patients attending TSC clinics had quicker diagnoses, with epilepsy being the most common symptom in older patients and cardiac rhabdomyoma in younger patients.
Evaluation of pathways involved in the protective effect of trans sodium crocetinate against contrast-induced nephropathy in rats.
Naunyn Schmiedebergs Arch Pharmacol
November 2024
Pharmaceutical Research Centre, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.
Contrast-induced nephropathy (CIN) is the most important side effect following contrast media application. The purpose of this study was to investigate the nephroprotective effects of trans sodium crocetinate (TSC) against sodium amidotrizoate/meglumine amidotrizoate (SAMA). Wistar rats were classified into eight groups (n = 6, male, 220-250 g) including (1) sham, injection of solvents (intraperitoneally; i.
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