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Background: Ruxolitinib cream has demonstrated anti-inflammatory and antipruritic activity and was well tolerated in a phase 3 study in patients aged 2-11 years with mild to moderate atopic dermatitis (AD).
Objective: This study examined the safety, tolerability, pharmacokinetics, efficacy, and quality of life (QoL) with ruxolitinib cream under maximum-use conditions and with longer-term use.
Methods: Eligible patients were aged 2-11 years with moderate to severe AD [Investigator's Global Assessment (IGA) score 3-4], and ≥ 35% affected body surface area (BSA).
Use of a virtual phantom to assess the capability of a treatment planning system to perform magnetic resonance image distortion correction.
Phys Eng Sci Med
January 2025
Physics Department, Instituto Zunino, Obispo Oro 423, X5000BFI, Córdoba, Argentina.
Treatment Planning Systems (TPS) offer algorithms for distortion correction (DC) of Magnetic Resonance (MR) images, whose performances demand proper evaluation. This work develops a procedure using a virtual phantom to quantitatively assess a TPS DC algorithm. Variations of the digital Brainweb MR study were created by introducing known distortions and Control Points (CPs).
View Article and Find Full Text PDFAssessment of industrial effluent discharges contributing to Ganga water pollution through a multivariate statistical framework: investigating the context of Indian industries.
Environ Sci Pollut Res Int
January 2025
Central Pollution Control Board, MoEF & CC, Government of India, New Delhi, India.
The swift industrial expansion has posed significant environmental challenges, particularly in the context of water pollution. Industrial effluents consist of substantial amounts of harmful pollutants that enter the main rivers via various tapped and untapped drains/local water streams, causing alterations in their physical and chemical properties. This study investigated 153 grossly polluting industries (GPIs) that were identified to release their effluents into the main rivers through different drains within multiple sectors in the industrial zone of four northern states of India in 2023.
View Article and Find Full Text PDFExploring pet owners' attitudes toward compounded and human approved medicines: a questionnaire based pilot study.
Vet Res Commun
January 2025
Department of Pharmacology and Toxicology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000, Novi Sad, Serbia.
With the growing global pet population and increased spending on veterinary care, compounded medications offer customized, often more suitable and affordable treatment options compared to the limited available veterinary medications. This research aims to understand pet owners' attitudes towards compounded medications, focusing on their challenges and needs. A total of 300 respondents from the territory of Novi Sad, province of Vojvodina, Republic of Serbia completed the questionnaire, through face-to-face interviews at veterinary clinics.
View Article and Find Full Text PDFSupercycle Al-Doped ZnMgO Alloys via Atomic Layer Deposition for Quantum Dot Light-Emitting Diodes.
ACS Appl Mater Interfaces
January 2025
Department of Photonics and Nanoelectronics, and BK21 FOUR ERICA-ACE Center, Hanyang University, Ansan 15588, Korea.
Colloidal quantum-dot light-emitting diodes (QD-LEDs) have been significantly improved in terms of device performance and lifetime by employing zinc oxide (ZnO) as an electron transport layer (ETL). Although atomic layer deposition (ALD) allows fabrication of uniform, high-quality ZnO films with minimal defects, the high conductivity of ZnO has hindered its straightforward application as an ETL in QD-LEDs. Herein, we propose fabrication of Al-doped ZnMgO (Al:ZnMgO) ETLs for QD-LEDs through a supercycle ALD, with alternating depositions of various metal oxides.
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