Syphilitic chorioretinitis is a rare manifestation of secondary syphilis. The Authors report a case of a patient tested positive for human immune deficiency virus. A 26-Year-old man presented with a history of suddenly blurred vision in the right eye. Because of a central scotoma, visual acuity was reduced to counting fingers. Slit-lamp examination found one-plus anterior chamber cells and one-plus vitreous cells. Results of ophthalmoscopic examination showed a large yellow lesion in the macular area with a papillar edema and peripheral vasculitis. Serum and cerebrospinal fluid were positive for syphilitic serology. Visual acuity improved to 20/20 after three courses of intravenous ceftriaxone (2g/day for 15 days). The fundus lesion resolved almost completely, resulting in slight pigmentary changes in the macular area. This case report highlights the need for syphilitic serology in cases of uveitis in immunocompromised patients.
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http://dx.doi.org/10.1016/s0181-5512(04)96143-8 | DOI Listing |
Am J Ophthalmol
March 2025
Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. Electronic address:
Objective: To determine the rate of unplanned return to operation room (OR) within 90 days of cataract surgery and to identify the most common pre-operative and intraoperative risk factors.
Design: Retrospective case-control study.
Subjects And Controls: Patients aged >= 40 years undergoing cataract surgery at the Wilmer Eye Institute between 2019-2022 with at least 90 days of postoperative follow-up were included.
Pediatrics
March 2025
Department of Ophthalmology, Virginia Commonwealth University, Richmond, Virginia.
A 13-month-old girl and a 3-year-old boy were referred to pediatric ophthalmology for leukocoria noticed on a smartphone photograph obtained by the family. Ophthalmologic examination revealed visual acuity appropriate for age and normal dilated fundus exams in both children without signs of retinoblastoma or other ocular abnormalities. Further review of the home photographs revealed optic nerve details in the leukocoric eyes.
View Article and Find Full Text PDFCornea
March 2025
Department of Ophthalmology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland.
Purpose: To evaluate the effect of customized corneal crosslinking on pellucid marginal degeneration (PMD).
Methods: Twenty-eight eyes with PMD were included. Fifteen eyes were treated with customized corneal crosslinking at Helsinki University Eye Hospital.
Int Ophthalmol
March 2025
Burapha University Hospital, Burapha University, Saen Suk, Chonburi, Thailand.
Background: Retinitis pigmentosa (RP) is a retinal dystrophy and genetically heterogeneous group that causes vision loss and necessitates innovative therapeutic strategies, and mesenchymal stem cell (MSC) therapy has shown potential due to its regenerative and immunomodulatory properties. This meta-analysis aims to evaluate the efficacy and safety of MSC therapies in improving visual outcomes, focusing on the impact of various MSC types, administration methods, and duration of benefits.
Methods: A systematic search of peer-reviewed studies was conducted to identify clinical trials and observational studies investigating MSC therapies for retinal conditions.
Doc Ophthalmol
March 2025
Department of Ophthalmology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan.
Purpose: To report our flicker electroretinographic (ERG) findings in a patient who developed uveitis after treatment with immune checkpoint inhibitors (ICIs) for a metastatic malignant melanoma.
Methods: ERGs were used to monitor retinal physiology in a patient with ocular complications following systemic ICI administration. Flicker ERGs were recorded using the RETeval system before and after the ICI treatments.
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