Garlic is reported to have beneficial effects on risk factors associated with cardiovascular disease, including normalization of plasma lipid levels. However, numerous studies do not support this beneficial effect of garlic on plasma lipids. This contradiction may result from the use of different garlic-derived materials, experimental designs, and/or animal models. The present study investigated the hypolipidemic effect of garlic-derived materials in APOE*3-Leiden mice, a model well suited for drug and dietary intervention studies of hyperlipidemia. APOE*3-Leiden mice were fed a garlic-derived sulfur-rich compound, either allicin (0.29 g.L drinking water(-1)) or diallyldisulfide (0.27 g.kg diet(-1)), or powdered garlic, of either the kwai (42 g.kg diet(-1)) or morado (42 g.kg diet(-1)) variety. The amounts of garlic-derived materials supplied allowed free intake of allicin or allicin equivalents (diallyldisulfide, kwai, or morado) at 44 mg.kg body wt(-1).d(-1). Mice were fed a nonpurified diet for 4 wk, followed by a Western diet for 8 wk, both supplemented with the garlic-derived materials. These diets had no consistent effect on plasma lipids and did not affect lipoprotein profiles, which are markers for whole-body cholesterol synthesis and intestinal sterol absorption. The current data indicate that the postulated effects of garlic on cardiovascular disease are not caused via modulation of plasma lipid levels.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1093/jn/134.6.1500 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Oral administration of garlic-derived nanoparticles improves cancer immunotherapy by inducing intestinal IFNγ-producing γδ T cells.
Nat Nanotechnol
October 2024
Laboratory for Biomaterial and ImmunoEngineering, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou, China.
Gamma-delta (γδ) T cell-based cancer immunotherapies represent a promising avenue for cancer treatment. However, their development is challenged by the limited expansion and differentiation of the cells ex vivo. Here we induced the endogenous expansion and activation of γδ T cells through oral administration of garlic-derived nanoparticles (GNPs).
View Article and Find Full Text PDFGarlic-Derived Exosome-like Nanovesicles-Based Wound Dressing for Infection Visualization and Treatment.
ACS Appl Bio Mater
March 2024
Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device, School of Chemistry and Chemical Engineering, Southeast University, Nanjing 211189, China.
Garlic-derived exosome-like nanovesicles (GELNs) could function in interspecies communication and may serve as natural therapeutics to regulate the inflammatory response or as nanocarriers to efficiently deliver specific drugs. () is able to hide within host cells to evade immune clearance and antibiotics, leading to life-threatening infections. On-site detection and efficient treatment of intracellular infection in wounds remain challenging.
View Article and Find Full Text PDFCombined Effects of Amino Acids in Garlic and Buna-Shimeji ( on Suppression of CCl-Induced Hepatic Injury in Rats.
Foods
June 2021
Department of Chemistry and Life Science, Nihon University, 1866 Kameino, Fujisawa-shi 252-0880, Japan.
The combination of the garlic-derived amino acid, -allyl-l-cysteine sulfoxide (ACSO), and ornithine or arginine on CCl-induced hepatic injury was examined. After investigating the effectiveness of the mixture of ACSO and ornithine or arginine in preventing hepatic injury in vivo, an extract rich in ACSO and ornithine was prepared by converting arginine in garlic to ornithine by arginase from (buna-shimeji), after screening the productivity of ornithine among 12 kinds of mushrooms. Co-administration of ACSO with ornithine or arginine suppressed the increase in aspartate transaminase, alanine transaminase, and thiobarbituric acid reactive substance, and the decrease in glutathione -transferase and cytochrome p450 2E1 activities after CCl injection more effectively than a single administration of ACSO.
View Article and Find Full Text PDF"One-Step" Carbonization Activation of Garlic Seeds for Honeycomb-like Hierarchical Porous Carbon and Its High Supercapacitor Properties.
ACS Omega
November 2020
School of Physics and Technology, and MOE Key Laboratory of Artificial Micro- and Nano-structures, Wuhan University, Wuhan 430072, China.
Article Synopsis
- A novel honeycomb-like hierarchical porous carbon (h-HPC) is created from carbonizing and activating garlic seeds, showing exceptional electrochemical properties for supercapacitor use.
- Optimal synthesis conditions for h-HPC are determined to be 700 °C carbonization temperature and a 1:1 mass ratio of KOH to garlic seeds, resulting in a specific surface area of 1417 m/g with a well-distributed pore size.
- When used as an electrode in supercapacitors, h-HPC achieves a specific capacitance of 268 F/g, delivers a high energy density of 31.7 Wh/kg, and maintains 99.2% capacitance after 10,000 cycles, indicating its potential
Effect of Cryopreservation on Plant Growth, Bulb Characteristics, and Virus Reduction of Garlic (Allium sativum L.).
Cryo Letters
January 2019
College of Horticulture, Northwest A&F University, Yangling, Shaanxi, People's Republic of China.
Background: Cryopreservation is a promising plant germplasm preservation technique that provides genetically stable plantlets.
Objective: To investigate whether the cryopreservation protocol developed for garlic compromises the performance of the cryopreserved plants, compared to garlic plants grown in the field.
Materials And Methods: The field performance of cryopreserved garlic plantlets under in vivo conditions was compared with garlic derived from the field.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!