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Nanosystems for Intranasal Delivery of Therapeutics in Psychiatric Disorders.
Curr Drug Deliv
January 2025
Neurosciences Research Center (NSRC), Tabriz University of Medical Sciences, Tabriz, Iran.
Due to the blood-brain barrier (BBB) and issues with oral and other traditional routes of administration, psychiatric disorders present significant challenges in getting therapeutics into the brain. The nose-to-brain pathway, also known as intranasal delivery, has shown promise in overcoming these barriers since it targets the brain directly and bypasses the BBB. This review explores nanocarriers' potential for intranasal delivery of therapeutics in the treatment of psychiatric disorders.
View Article and Find Full Text PDFA Review of Basic Fibroblast Growth Factor Delivery Strategies and Applications in Regenerative Medicine.
J Biomed Mater Res A
January 2025
Department of Pharmacy, Yueqing Third People's Hospital, Wenzhou, China.
Basic fibroblast growth factor (bFGF) is a significant member of the fibroblast growth factor (FGF) family. The bFGF has a three-dimensional structure comprising 12 reverse parallel β-folds. This structure facilitates tissue wound repair, angiogenesis, bone formation, cartilage repair, and nerve regeneration.
View Article and Find Full Text PDFTransdermal delivery of natural products against atopic dermatitis.
Chin J Nat Med
December 2024
Department of Pharmacy, Ningbo Municipal Hospital of Traditional Chinese Medicine (TCM), Affiliated Hospital of Zhejiang Chinese Medical University, Ningbo 315010, China. Electronic address:
Atopic dermatitis (AD) is a chronic inflammatory skin condition. Natural products have gained traction in AD treatment due to their accessibility, low toxicity, and favorable pharmacological properties. However, their application is primarily constrained by poor solubility, instability, and limited permeability.
View Article and Find Full Text PDFTargeted lipid nanoparticles distributed in hydrogel treat osteoarthritis by modulating cholesterol metabolism and promoting endogenous cartilage regeneration.
J Nanobiotechnology
December 2024
Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, 250021, People's Republic of China.
Article Synopsis
- Osteoarthritis (OA) is a common joint disease characterized by cartilage destruction and inflammation, recognized as a metabolic disease linked to cholesterol metabolism in chondrocytes.
- A new study combines bioactive hydrogels that recruit stem cells with lipid nanoparticles to create a regenerative environment for treating OA.
- This method promotes the differentiation of stem cells into chondrocytes and improves inflammation, presenting a promising nonsurgical treatment option for cartilage restoration in OA patients.
Artificial intelligence-driven hydrogel microneedle patches integrating 5-fluorouracil inclusion complex-loaded flexible pegylated liposomes for enhanced non-melanoma skin cancer treatment.
Int J Pharm
January 2025
Pharmaceutical Development of Green Innovations Group (PDGIG), Department of Industrial Pharmacy, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom, Thailand; Research and Innovation Center for Advanced Therapy Medicinal Products, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand. Electronic address:
The current study focused on the development of crosslinked hydrogel microneedle patches (cHMNs) incorporating 5-FU-hydroxypropyl beta-cyclodextrin inclusion complex-loaded flexible PEGylated liposomes (5-FU-HPβCD-loaded FP-LPs) to enhance treatment efficacy and reduce drug toxicity. The research utilized artificial intelligence (AI) algorithms to design, optimize, and evaluate the cHMNs. Various AI models were assessed for accuracy, with metrics such as root mean square error and coefficient of determination guiding the selection of the most effective formulation.
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