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Effect of proposed asynchronous injection strategy on the combination therapy of magnetic hyperthermia and thermosensitive liposome.
J Therm Biol
January 2025
College of Electrical Engineering and Automation, Fuzhou University, Fuzhou, 350116, China.
Magnetic nanoparticles (MNPs) used for magnetic hyperthermia can not only damage tumor cells after elevating to a specific temperature but also provide the temperature required for thermosensitive liposomes (TSL) to release doxorubicin (DOX). MNPs injected into tumor will generate heat under an alternating magnetic field, so the MNPs distribution can determine temperature distribution and further affect the DOX concentration used for tumor therapy. This study proposes an asynchronous injection strategy for this combination therapy in order to improve the DOX concentration value for drug therapy, in which the MNPs are injected into tumor after a certain lagging of TSL injection in order to increase the TSL concentration inside tumor.
View Article and Find Full Text PDFEffective Use of DCM Root Extract Encapsulated by Thermosensitive Immunoliposomes for Targeted Drug Delivery in Prostate Cancer Cells.
Curr Issues Mol Biol
October 2024
Department of Pharmacology, University of the Free State, Bloemfontein 9300, South Africa.
Article Synopsis
- * Liposomes were created with a specific ratio of components and attached to a PSA antibody, successfully encapsulating anticancer drugs (doxorubicin and docetaxel) alongside plant extracts.
- * The study found that heating the liposomes to 39-40 °C activated them, releasing their contents and effectively inhibiting the growth of prostate cancer cell lines (LNCap and DU145) when compared to non-heated conditions.
Dual structure on-demand release chitosan-based coating film for peach preservation.
Int J Biol Macromol
December 2024
College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:
After harvest, fruits and vegetables go through the stages of storage, transportation and sales, and how to regulate the role of preservative in different stages is an urgent problem to be solved. Herein, chitosan-stearic acid is synthesized, then interacting with trans-2-hexenal (E2H) to prepare nanoclusters. Subsequently, the temperature-sensitive liposomes were designed to encase E2H by using the special temperature-responsive open-chain phospholipids, and then combined with chitosan to obtain chitosan-based coating film for peach preservation.
View Article and Find Full Text PDFAdipocyte-Targeted Nanocomplex with Synergistic Photothermal and Pharmacological Effects for Combating Obesity and Related Metabolic Syndromes.
Nanomaterials (Basel)
August 2024
NHC Key Laboratory of Hormones and Development, Chu Hsien-I Memorial Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin 300134, China.
Article Synopsis
- Obesity is a widespread issue linked to various metabolic disorders, and browning white adipose tissue (WAT) is seen as a potential treatment to help with weight loss and metabolic health.
- Researchers developed a nanocomplex called pTSL@(P+I), which uses temperature-sensitive liposomes that target adipocytes and carry agents that promote browning and harness photothermal properties.
- In studies with diet-induced obesity mice, this nanocomplex showed significant weight loss (14.4% reduction) and improved fat/lean mass ratio without major side effects, highlighting its potential as a targeted therapy for obesity.
Octa-Arginine-Conjugated Liposomal Nimodipine Incorporated in a Temperature-Responsive Gel for Nasoencephalic Delivery.
Mol Pharm
October 2024
College of Pharmacy, Yanbian University, Yanji 133002, Jilin, China.
Nimodipine is the primary clinical drug used to treat cerebral vasospasm following subarachnoid hemorrhage. Currently, tablets have low bioavailability when taken orally, and injections contain ethanol. Therefore, we investigated a new method of nimodipine administration, namely, nasoencephalic administration.
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