No recent studies of organ weights of normal infants exist. We completed a 15-year retrospective study of organ weights of normal infants who died between 1986 and 2000 in an effort to update the "normal" weight standards for infants up to one year of age. Additionally, we compared organ weights of infants whose deaths were ruled Sudden Infant Death Syndrome (SIDS) with those of other natural or non-natural causes within the same age groups, length and total body weight at autopsy, total organ weight as a percentage of total body weight, and with weight standards based on previous studies. This study included 453 autopsied infants in Kent County, Michigan, and who were referred to our facility by surrounding counties. All subjects were autopsied at Spectrum Health Blodgett Campus in Grand Rapids, Michigan.
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J Genet Genomics
January 2025
State Key Laboratory of Maize Bio-breeding, Key Laboratory of Genome Editing Research and Application, Ministry of Agriculture and Rural Affairs, Department of Plant Genetics and Breeding, National Maize Improvement Center, College of Agronomy and Biotechnology, China Agricultural University, Beijing 100193, China; Frontiers Science Center for Molecular Design Breeding, Beijing 100193, China. Electronic address:
Transcription factors play critical roles in the regulation of gene expression during maize kernel development. The maize endosperm is a large storage organ, accounting for nearly 90% of the dry weight of mature kernel, and is also the main place for starch storage. In this study, we identify an endosperm-specific EREB gene, ZmEREB167, which encodes a nucleus-localized EREB protein.
View Article and Find Full Text PDFActa Bioeng Biomech
September 2024
Institute of Advanced Research for Sport and Health Science, Ritsumeikan University, Japan.
: Toe flexor strength (TFS) has been determined to evaluate the toe flexor muscle function. However, it is unclear how strength and size relationships of toe flexor muscles vary depending on the toes intended for force production. We aimed to clarify this by examining the relationship between TFS and toe flexor muscle size, and hypothesized TFS produced by all toes (TFS-All), the great toe (TFS-Great) and lesser toes (TFS-Lesser) would be specifically associated with the size of the muscles specialized in each corresponding toe flexion.
View Article and Find Full Text PDFFront Immunol
January 2025
Division of Urology, Department of Surgery, Endeavor Health (formerly NorthShore University HealthSystem), Evanston, IL, United States.
Introduction: Macrophages exhibit marked phenotypic heterogeneity within and across disease states, with lipid metabolic reprogramming contributing to macrophage activation and heterogeneity. Chronic inflammation has been observed in human benign prostatic hyperplasia (BPH) tissues, however macrophage activation states and their contributions to this hyperplastic disease have not been defined. We postulated that a shift in macrophage phenotypes with increasing prostate size could involve metabolic alterations resulting in prostatic epithelial or stromal hyperplasia.
View Article and Find Full Text PDFToxicol Pathol
January 2025
Charles River Laboratories Edinburgh Ltd, Elphinstone Research Centre, Tranent, UK.
A retrospective study was performed to determine the incidences of spontaneous findings in control laboratory New Zealand White (NZW) and Dutch Belted (DB) rabbits. Terminal body and organ weights data were also collected. A total of 2170 NZW (526 males/1644 females), 100 DB rabbits (50 animals per sex), aged 4- to 7-month-old were obtained from 158 non-clinical studies evaluated between 2013 and 2022.
View Article and Find Full Text PDFAlzheimers Res Ther
January 2025
Department of Neurology, University Medical Center Rostock, 18147, Rostock, Germany.
Background: Degeneration of the basal forebrain cholinergic system is a hallmark feature shared by Alzheimer's disease (AD) and Lewy body disease (LBD) whereas hippocampus atrophy is more specifically related to AD. We aimed to investigate the relationship between basal forebrain and hippocampus atrophy, cognitive decline, and neuropathology in a large autopsy sample.
Methods: Data were obtained from the National Alzheimer's Coordinating Center (NACC).
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