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Pharmacogenetic and pharmacogenomic treatment of rheumatoid arthritis: a review of Pharmacogenomics Knowledge Base scientific evidence.
Pharmacogenomics
January 2024
MEPER Group Clinical and Translational Research in Pharmacogenetics and Personalized Medicine and Mental Health, Biosanitary University Research Institute of Extremadura (INUBE), Badajoz, 06080, Spain.
Tweetable abstract Update on the genetic variants with the highest level of Pharmacogenomics Knowledge Base evidence for their association with toxicity and efficacy in response to the most commonly used disease-modifying antirheumatic drugs for the treatment of rheumatoid arthritis.
View Article and Find Full Text PDFPhysicians establish diagnosis by assessing a patient's signs, symptoms, age, sex, laboratory test findings and the disease history. All this must be done in limited time and against the backdrop of an increasing overall workload. In the era of evidence-based medicine it is utmost important for a clinician to be abreast of the latest guidelines and treatment protocols which are changing rapidly.
View Article and Find Full Text PDFPharmVar GeneFocus: CYP3A5.
Clin Pharmacol Ther
December 2022
Division of Clinical Pharmacology, Toxicology & Therapeutic Innovation, Children's Mercy Kansas City, Kansas City, Missouri, USA.
The Pharmacogene Variation Consortium (PharmVar) catalogs star (*) allele nomenclature for the polymorphic human CYP3A5 gene. Genetic variation within the CYP3A5 gene locus impacts the metabolism of several clinically important drugs, including the immunosuppressants tacrolimus, sirolimus, cyclosporine, and the benzodiazepine midazolam. Variable CYP3A5 activity is of clinical importance regarding tacrolimus metabolism.
View Article and Find Full Text PDFGenetic variation of pharmacogenomic VIP variants in the Chinese Li population: an updated research.
Mol Genet Genomics
March 2022
Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University, Xi'an, 710069, Shaanxi, China.
Article Synopsis
- * Researchers successfully analyzed 52 VIP variants in 27 genes among 200 individuals from the Li population and found significant differences, particularly in SNPs related to drug metabolism.
- * Four specific gene variants (KCNH2, ACE, CYP4F2, CYP2E1) were highlighted for their potential to predict drug efficacy and adverse reactions, enhancing pharmacogenomic understanding for the Li population.
Development of a bioinformatics platform for analysis of quantitative transcriptomics and proteomics data: the OMnalysis.
PeerJ
November 2021
Laboratory of Biomedical Microbiology and Immunology, University of Veterinary Medicine and Pharmacy in Kosice, Kosice, Slovakia.
Background: In the past decade, RNA sequencing and mass spectrometry based quantitative approaches are being used commonly to identify the differentially expressed biomarkers in different biological conditions. Data generated from these approaches come in different sizes (, count matrix, normalized list of differentially expressed biomarkers, etc.) and shapes (, sequences, spectral data, etc.
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