AI Article Synopsis
- The study investigates the roles of acetyl-heparanase mRNA, laminin (LN), and laminin receptor (LR) in different ovarian cancer types to understand their involvement in metastasis.
- Results showed that acetyl-heparanase mRNA levels were significantly higher in ovarian carcinoma and metastatic lymph nodes compared to benign tumors, with a notable difference in expression patterns.
- The findings suggest that acetyl-heparanase mRNA, along with decreased LN and increased LR expression, may play a key role in the growth and spread of ovarian cancer.
Article Abstract
Aim: To explore the expressions of acetyl-heparanase mRNA, laminin ( LN) and laminin receptor ( LR) in 50 ovarian carcinoma, 33 ovarian carcinoma with lymph node metastasis, and 10 serous ovarian cystadenoma as well as their role in the metastasis of ovarian cancer.
Methods: The transcription level of acetyl-heparanase mRNA, expressions of LN and LR were detected by in situ hibridization and immunohistochemical staining, respectively.
Results: The transcription level of acetyl-heparanase mRNA in ovarian carcinoma tissue and metastatic lymph nodes increased significantly, but its expression in primary focus was notably higher than that in metastatic lymph nodes (P < 0. 05 ). There was low expression of acetyl-heparanase mRNA in serous ovarian cystadenoma. The expression of acetyl-heparanase mRNA in malignant and benign tumor tissues had markedly difference (P < 0. 01 ). Expressions LN in both tissues mentioned above decreased while LR expression was high. The expression of acetyl-heparanase mRNA was negative correlation with that of LN, while positive with that of LR.
Conclusion: The correlation among expressions of acetyl-heparanase mRNA, LN and LR suggests that heparanase is involved in the growth, invasion and metastasis of ovarian carcinoma.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
[The expression of acetyl-heparanase, laminin and laminin receptor and their role in the metastasis of ovarian cancer].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
September 2003
Department of Obstetrics and Gynecology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.
Article Synopsis
- The study investigates the roles of acetyl-heparanase mRNA, laminin (LN), and laminin receptor (LR) in different ovarian cancer types to understand their involvement in metastasis.
- Results showed that acetyl-heparanase mRNA levels were significantly higher in ovarian carcinoma and metastatic lymph nodes compared to benign tumors, with a notable difference in expression patterns.
- The findings suggest that acetyl-heparanase mRNA, along with decreased LN and increased LR expression, may play a key role in the growth and spread of ovarian cancer.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!