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Acute Generalized Exanthematous Pustulosis in a 76-year-Old Man With Neuroendocrine Carcinoma of the Lung, Responsive to Ixekizumab.
Clin Cosmet Investig Dermatol
February 2025
Guangzhou Dermatology Hospital, Guangzhou, Guangdong, People's Republic of China.
Acute generalized exanthematous pustulosis (AGEP) is a rare, painful, and pruritic drug-induced rash characterized by sterile pustules on an erythematous base, followed by desquamation. While commonly induced by antibiotics, cases associated with antineoplastic drugs have become more frequent in recent years. Here, we report a 76-year-old Chinese male with lung large-cell neuroendocrine carcinoma who developed erythema and pustules on his left lower leg, which spread to the trunk and limbs after the fourth cycle of immunotherapy and chemotherapy.
View Article and Find Full Text PDFHickam's Dictum Prevails: Kaposi Sarcoma and Primary Effusion Lymphoma in a Person Living With Human Immunodeficiency Virus (HIV) and Human Herpesvirus 8 (HHV-8) Infection.
Cureus
January 2025
Internal Medicine, Rob Ferreira Tertiary Hospital, Nelspruit, ZAF.
Human immunodeficiency virus (HIV) infection has a plethora of effects on its host, including increased susceptibility to opportunistic infections and increased likelihood of developing HIV-associated malignancies. The combined cellular dysfunction orchestrated by co-infection with oncogenic viruses, such as human herpesvirus-8 (HHV-8) and Epstein-Barr virus (EBV), further amplifies the risk of malignancy in people living with HIV/AIDS (PLHA). We report a rare case of Kaposi sarcoma (KS) and extra cavitary primary effusion lymphoma (EPEL) in a 48-year-old woman with advanced HIV disease on antiretroviral treatment presenting with arthralgia, generalized body weakness, drenching night sweats, cavitary effusions, a violaceous rash on her left leg, as well as generalized lymphadenopathy.
View Article and Find Full Text PDFLong-term outcomes of enzyme replacement therapy from a large cohort of Korean patients with mucopolysaccharidosis IVA (Morquio A syndrome).
Mol Genet Metab Rep
March 2025
Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
Mucopolysaccharidosis (MPS) IVA (Morquio A syndrome) is an autosomal recessive lysosomal storage disorder caused by a mutation affecting the enzyme -acetylgalactosamine-6-sulfatase (EC 3.1.6.
View Article and Find Full Text PDFA Challenging Case of Eosinophilic Fasciitis Without Classic Histopathological Findings.
Perm J
March 2025
Department of Dermatology, La Mesa Medical Offices, Southern California Permanente Medical Group, La Mesa, CA, USA.
Eosinophilic fasciitis (EF) is a rare dermatologic disease with clinical similarities to localized scleroderma and systemic sclerosis (SSc). Diagnosing EF is challenging due to overlapping clinical features among these conditions. Differentiating EF from localized scleroderma and SSc can be aided by laboratory tests, histopathological examination, and imaging studies.
View Article and Find Full Text PDFAmyotrophic lateral sclerosis in a patient with chronic lymphocytic leukaemia and drug related sarcoid-like reaction.
BMC Neurol
January 2025
Department of Neurology, Wessex Neurological Centre, University Hospital Southampton, Southampton, UK.
Article Synopsis
- Sarcoid-like reaction (SLR) is an immune response affecting lymph nodes and organs, which doesn't fulfill the criteria for systemic sarcoidosis, and can be associated with certain diseases like Chronic lymphocytic leukaemia (CLL) and Amyotrophic lateral sclerosis (ALS).
- A 60-year-old male patient with treated CLL developed ALS symptoms following exposure to Venetoclax and Rituximab, presenting with rashes and weakness that progressed over a year.
- Diagnosis complications included atypical signs and symptoms, leading to misdiagnosis of neurosarcoidosis and challenges in treatment, despite initial interventions with prednisolone and infliximab.
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