Introduction: Psychosocial therapy programs have been effective in relapse prevention, symptoms control, and functional improvement in patients with schizophrenia. Accordingly, and in addition to medication, they are currently an indicated therapy component. Therapy efficacy of the package used in this study was positive in short-term follow-ups and is now appropriate to analyze them four years later.
Method: Clinical and social functioning effects of a psychosocial intervention package, consisting of psychoeducation and integrated psychological therapy (IPT) with patients, and psychoeducation, behavioral therapy and problem solving training with families, were studied in 20 out-patients with schizophrenia (using pre-treatment, post-treatment and four-year follow-up measures).
Results: Within groups results indicate a sustained improvement in the treatment group as compared to a 15 out-patients comparison group that received standard treatment. All participants were on stable regimens of antipsychotic medications. After the follow-up period, however, between groups differences tend to diminish.
Conclusions: The overall findings indicated that this package has produced encouraging effects still apparent in the 4 year follow-up. However, the intervention procedure merits further investigation, and suggestions are made to keep a low-level, long-lasting psychosocial intervention, adapted to each patient's needs.
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Semin Oncol Nurs
January 2025
School of Nursing, Midwifery and Health Systems, University College Dublin (UCD), Dublin, Ireland.
Objective: To conceptualize rumination in adult cancer care.
Methods: Walker and Avant's concept analysis method was used to examine rumination in adults with cancer. A systematic search was conducted across psychology, nursing, medicine, and public health disciplines in PsycINFO, PubMed, Web of Science, CINAHL, and Scopus databases from their inception to April 2024.
Int J Biol Macromol
January 2025
Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, China; The Grade 3 Pharmaceutical Chemistry Laboratory of State Administration of Traditional Chinese Medicine, Hefei 230022, China. Electronic address:
Synovial hyperplasia, inflammation and immune cell infiltration are the central pathological basis of rheumatoid arthritis (RA). Nonetheless, the cellular, molecular and immunological mechanisms of RA remain poorly understood. An integrated analysis of single-cell RNA (scRNA) and bulk RNA sequencing datasets aimed to unravel the cellular landscape, differentiation trajectory, transcriptome signature, and immunoinfiltration feature of RA synovium.
View Article and Find Full Text PDFInt J Geriatr Psychiatry
January 2025
Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan.
Objectives: The diagnosis of early-onset Alzheimer's disease (EOAD) can cause emotional stress not only to the patients themselves but also to their spouses. This study aimed to evaluate the risk of psychiatric disorders in spouses of EOAD patients, using psychotropic drug initiation as a surrogate indicator.
Methods: A cohort study was conducted using a Japanese claims database, with spouses of EOAD patients (exposed spouses) matched with spouses of non-EOAD individuals (reference spouses) up to a 1:10 ratio.
BMC Psychol
January 2025
Department of Medical Psychology, Air Force Medical University, Xi'an, China.
Purpose: The purpose of this study was to use the advanced technique of Network Intervention Analysis (NIA) to investigate the trajectory of symptom change associated with the effects of self-control training on youth university students' chronic ego depletion aftereffects.
Methods: The nine nodes of chronic ego depletion aftereffects and integrated self-control training were taken as nodes in the network and analyzed using NIA. Networks were computed at the baseline, at the end of treatment, at 1-, 3-, 6-, 9- and 12-month follow up.
BMC Health Serv Res
January 2025
Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK.
Background: Given the increasing recognition of the value of greater integration of physical and mental health services for children and young people, we aimed to evaluate preferences among parents for the characteristics associated with integrated health service provision for two conditions (eating disorders, functional symptom disorders).
Methods: Two discrete choice experiments (DCEs) were conducted, using electronic surveys. Participants were adult parents of children and young people.
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