The Autogenic Training (AT) is a well established relaxation technique and psychotherapy tool. We report the use of nonlinear routines, the Multi-scaled Time-Frequency-Distribution (mTFD) for the graphical display of vegetative rhythms, and Post-Event-Scan (PES) for the direct visual identification of coupling between physiological subsystems. Applying these methods to time series of respiration, arterial blood pressure, and cutaneous forehead blood content fluctuations in controls (n = 11) or AT-experts (ATE, n = 11) induced psychomotor drive reduction during orthostatic stress allowed the instantaneous identification of a 0.15 Hz-rhythm. This rhythm prevailed in ATE significantly longer resulting a significantly robust 1 : 1 coupling between cutaneous blood content fluctuations and respiration. Consequently, we hypothesize that the "0.15 Hz-rhythm" in the cutaneous blood content fluctuations described previously which was associated with the subjective experience of profound psychomotor relaxation reflects an order-order transition in peripheral signals of central nervous origin. Results produced with the aid of these analytic tools support the efficacy of the AT induced, synergetic relaxation response.
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http://dx.doi.org/10.1055/s-2003-814877 | DOI Listing |
Int J Clin Pharm
January 2025
Department of Clinical Pharmacology and Pharmacy, Amsterdam University Medical Centers, Location VUMC, Amsterdam, The Netherlands.
Background: Deprescribing inappropriate cardiovascular and antidiabetic medication has been shown to be feasible and safe. Healthcare providers often perceive the deprescribing of cardiovascular and antidiabetic medication as a challenge and therefore it is still not widely implemented in daily practice.
Aim: The aim was to assess whether training focused on conducting a deprescribing-oriented clinical medication review (CMR) results in a reduction of the inappropriate use of cardiovascular and antidiabetic medicines.
Introduction: The developed domestic retrodipeptide analogue of cholecystokinin tetrapeptide (CCK) (N-(6-phenylhexanoyl)-glycyltryptophan amide, or compound GB-115) with antagonistic properties in relation to CCK1 receptors has anxiolytic activity previously shown in preclinical and clinical studies. The aim of the study was to evaluate the anxiolytic effect of GB-115 as a tablet form with subchronic oral administration in comparison with phenazepam in nonhuman primates.
Materials And Methods: The study was conducted on four male rhesus monkeys (Macaca mulatta) aged 5.
J Am Coll Cardiol
January 2025
SKL-ESPC & SEPKL-AERM, College of Environmental Sciences and Engineering, Center for Environment and Health, Peking University, Beijing, China; Research Station of Alpine Ecology Environment and Health at Tibet University, Lhasa, Tibet Autonomous Region, China. Electronic address:
Background: Epidemiological studies reported associations between ozone (O) exposure and cardiovascular diseases, yet the biological mechanisms remain underexplored. Hypoxia is a shared pathogenesis of O-associated diseases; therefore, we hypothesized that O exposure may induce changes in hypoxia-related markers, leading to adverse cardiovascular effects.
Objectives: This study aimed to investigate associations of short-term O exposure with hypoxic biomarkers and arterial stiffness.
J Am Coll Cardiol
January 2025
Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health (GmbH), Neuherberg, Germany; Institute for Medical Information Processing, Biometry, and Epidemiology, Medical Faculty, LMU Munich, Munich, Germany.
JACC Heart Fail
January 2025
Center for Primary Health Care Research, Department of Clinical Sciences, Lund University, Malmö, Sweden; University Clinic Primary Care Skåne, Region Skåne, Sweden.
Background: Adverse pregnancy outcomes, such as preterm delivery and hypertensive disorders of pregnancy, may be associated with higher future risks of heart failure (HF). However, the comparative effects of different adverse pregnancy outcomes on long-term risk of HF, and their potential causality, are unclear.
Objectives: The authors sought to examine 5 major adverse pregnancy outcomes in relation to long-term risk of HF in a large population-based cohort.
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