Graft thrombosis in long-term postoperative period after lower extremity arterial reconstructions often results in limb loss. In some studies prolonged antithrombotic therapy was demonstrated to improve long-term patency of vascular grafts. Nevertheless little consensus exists on the optimal antithrombotic agents. The paper reviews publications on the problem. Oral anticoagulants seem to be feasible for reconstructions with poor outflow. In such cases strict laboratory monitoring of blood coagulation system is mandatory to prevent hemorrhagic complications.
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