Utilizing a human cytomegalovirus-specific fusion inhibitor and an antiglycoprotein H antibody, we studied the role of virion fusion in interferon-stimulated gene (ISG) induction. Our results indicate that ISG induction does not occur when virion-mediated, post-high-affinity attachment events are inhibited by either reagent. Thus, virion-mediated postattachment events, such as fusion, are required for ISG induction.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC416537 | PMC |
| http://dx.doi.org/10.1128/JVI.78.12.6688-6691.2004 | DOI Listing |
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