AI Article Synopsis
- - A fluoro version of the enolate intermediate used in type II dehydroquinases was created from (-)-quinic acid through a process with seven steps.
- - This new compound has been demonstrated to be the most effective inhibitor of the type II enzyme found in Mycobacterium tuberculosis.
- - The research highlights the potential for developing stronger inhibitors to combat tuberculosis using modifications of natural compounds.
Article Abstract
The fluoro analogue of the enolate intermediate in the reaction catalyzed by type II dehydroquinases has been prepared from naturally occurring (-)-quinic acid over seven steps and has been shown to be the most potent inhibitor reported to date of the type II enzyme from Mycobacterium tuberculosis.
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| http://dx.doi.org/10.1039/b404535a | DOI Listing |
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