After the study of different phenylselanyl group activators, halogenation by N-bromosuccinimide (NBS) has been shown to be the most suitable manner for cyclizing beta-phenylselanyl amines into aziridines and also enabled production of oxazolidin-2-ones from N-Boc beta-phenylselanyl amines in excellent yield.
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http://dx.doi.org/10.1039/b406566m | DOI Listing |
Brain Res
February 2024
Laboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Neurobiotechnology Research Group, Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS 96010-900, Brazil. Electronic address:
The serotonin type 4 receptor (5-HTR)shows promise as a target for treating major depressive disorder (MDD). Studies have demonstrated that 5-HTR agonists have a faster antidepressant-like effect compared to conventional medications. Developing drugs that modulate this receptor could lead to faster and more effective MDD treatments.
View Article and Find Full Text PDFMolecules
June 2023
Laboratório de Síntese Orgânica Limpa-LaSOL-CCQFA, Universidade Federal de Pelotas-UFPel, P.O. Box 354, Pelotas 96010-900, RS, Brazil.
A general methodology to access valuable 4-(phenylchalcogenyl)tetrazolo[1,5-]quinolines was developed by the reaction of 2-azidobenzaldehyde with phenylchalcogenylacetonitriles (sulfur and selenium) in the presence of potassium carbonate (20 mol%) as a catalyst. The reactions were conducted using a mixture of dimethylsulfoxide and water (7:3) as solvent at 80 °C for 4 h. This new methodology presents a good functional group tolerance to electron-deficient and electron-rich substituents, affording a total of twelve different 4-(phenylchalcogenyl)tetrazolo[1,5-]quinolines selectively in moderate to excellent yields.
View Article and Find Full Text PDFRSC Adv
May 2023
Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University 7 Gagarin Street 87-100 Torun Poland
Organoselenium compounds are well-known for their unique biological properties, including antioxidant, anticancer and anti-inflammatory. They result from the presence of a particular Se-moiety enclosed in a structure that provides physicochemical features necessary for effective drug-target interactions. Looking for a proper drug design that considers the influence of each structural element has to be conducted.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
July 2023
Programa de Pós-graduação em Bioquímica e Bioprospecção, Laboratório de Bioquímica e Neurofarmacologia Molecular (LABIONEM), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas (UFPel), CEP 96010-900 Pelotas, RS, Brazil. Electronic address:
Synthetic glucocorticoid administration has been reported to play a role in depression and cognitive decline. The present study investigated the 2-phenyl-3-(phenylselanyl)benzofuran (SeBZF1) effects against the depressive-like behavior, memory impairment, and neurochemical alterations caused by acute dexamethasone administration in female Swiss mice. A dexamethasone dose-response curve (0.
View Article and Find Full Text PDFOrg Biomol Chem
November 2022
LASOL-CCQFA, Universidade Federal de Pelotas - UFPel, P.O. Box 354, 96010-900, Pelotas, RS, Brazil.
We report a strategy for the direct synthesis of 3-organylselanylthiochromones and 3-organylselanylchromones the radical cyclization reaction between alkynyl aryl ketones containing an -thiopropyl/methoxy group and diorganyl diselenides promoted by Oxone®. This method allows the construction and -functionalization of thiochromones and chromones using Oxone® as a stable and non-hazardous oxidizing agent in the presence of CHCN at 82 °C. These reactions tolerate a variety of substituents, and allowed the synthesis of twenty-one new 3-organylselanylthiochromones and selanylchromones in good to excellent yields (55-95%).
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