Background: Squamous cell carcinomas of the head and neck (SCCHN) are the most frequent malignancies in this region. Down-regulation of human leukocyte antigen (HLA) class I was found to be implicated in the immune escape of these tumors.
Materials And Methods: Cell surface expression levels of several HLA class I antigens were evaluated in 21 SCCHN cell lines utilizing FACS analysis.
Results: Expression levels of HLA-antigens varied significantly between the investigated cell lines. On average higher HLA-B27 expression levels were observed in cell lines from younger and female patients.
Conclusion: Our data confirms down-regulation of HLA class I to be an important event in SCCHN. However, since several SCCHN cell lines also exhibited high HLA levels, other mechanisms than HLA down-regulation also need to be considered as a cause for disease progression. Further studies will be required to elucidate the potential role of HLA-B27 in SCCHN.
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