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Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain.
Proc Natl Acad Sci U S A
February 2025
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dundee DD1 5EH, United Kingdom.
Mutations in Leucine-rich repeat kinase 2 (LRRK2) and PTEN-induced kinase 1 (PINK1) are associated with familial Parkinson's disease (PD). LRRK2 phosphorylates Rab guanosine triphosphatase (GTPases) within the Switch II domain while PINK1 directly phosphorylates Parkin and ubiquitin (Ub) and indirectly induces phosphorylation of a subset of Rab GTPases. Herein we have crossed LRRK2 [R1441C] mutant knock-in mice with PINK1 knock-out (KO) mice and report that loss of PINK1 does not impact endogenous LRRK2-mediated Rab phosphorylation nor do we see significant effect of mutant LRRK2 on PINK1-mediated Rab and Ub phosphorylation.
View Article and Find Full Text PDFThe American Journal of Occupational Therapy (AJOT) is the official journal of the American Occupational Therapy Association (AOTA). The primary mission of AJOT is to publish peer-reviewed research examining the effectiveness and efficacy of occupational therapy practice so that occupational therapy professionals can make informed, evidence-based decisions about best practice. In addition, the journal aims to publish (1) research documenting the reliability and validity of occupational therapy instruments; (2) studies demonstrating a relationship between occupational engagement and the facilitation of community participation and health; and (3) articles that provide a forum for scholars to debate professional issues that affect education, practice, and research.
View Article and Find Full Text PDFEvaluating the biological impact of shelters on astronaut health during different solar particle events: a Geant4-DNA simulation study.
Radiat Environ Biophys
January 2025
Ionizing and Non-Ionizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences, Shiraz, Iran.
Mechanistic Monte Carlo simulations have proven invaluable in tackling complex challenges in radiobiology, for example for protecting astronauts from solar particle events (SPEs) during deep space missions which remains an underexplored area. In this study, the Geant4-DNA Monte Carlo code was used to assess the DNA damage caused by SPEs and evaluate the protective effectiveness of a multilayer shelter. By examining the February 1956 and October 1989 SPEs-two extreme cases-the results showed that the proposed shelter reduced DNA damage by up to 57.
View Article and Find Full Text PDFThe leadership expectations statement: A simple tool for enhancing leadership in healthcare organizations.
Health Serv Manage Res
February 2025
LSU Shreveport, Shreveport, LA, USA.
Healthcare organizations are reliant on cadres of managers to oversee operations, ensuring the delivery of excellent patient care and accomplishment of institutional missions. These managers obviously must be well versed in the principles of management, but they also must be proficient in leadership. As leadership can take many different forms, healthcare organizations must take care in their associated leadership development efforts to ensure that they have a firm grasp on the precise leadership qualities needed within their given organizations.
View Article and Find Full Text PDFNeutralizing Anti-SARS-CoV-2 Antibody Response to COVID-19 Vaccines-ChAdOx1-nCoV-19 and BBV152 Among Hemodialysis Patients.
Indian J Nephrol
July 2024
Department of Statistics, Nitte University, Bangalore, India.
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