18 Patients with calcifying odontogenic cyst underwent surgery in our Department from 1977 to 1993 were reported.8 male and 10 female aged from 11 to 52 with medium or 33 years were included.16 cases were pathologically confirmed as primary intraosseous cyst(central),and 2 as extraosseous cyst(peripheral).There was no recurrence after the local excision for preripheral calcifying odontogenic cyst and local curettage for central one.There were 3 in 6 cases of tumor typed cyst who had recurred postoperatively,two of them had recurred repeatedly and cured by means of local radiotherapy.The authors recommend that the tumor type of intraosseous calcifying odontogenic cyst be classified as a border-line tumor and treated as well as the principles of low malignant tumor.Post-operative radiotherapy could be used for recurrent cases.
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Case Rep Dent
January 2025
Oral Pathology, Faculty of Medicine and Health Sciences, Universidad Mayor, Santiago, Chile.
A calcifying odontogenic cyst (COC) is a cystic lesion originating from odontogenic epithelium, exhibiting ameloblastomatous features and containing focal accumulations of ghost cells. The standard treatment for COC typically involves enucleation followed by surgical curettage. However, if the cyst is large or closely associated with anatomical structures, decompression may be considered as a preliminary step before enucleation.
View Article and Find Full Text PDFJ Microsc Ultrastruct
December 2022
Department of Oral Pathology, D.Y. Patil Deemed to be University, D.Y. Patil School of Dentistry, Nerul, Navi Mumbai, Maharashtra, India.
Background: The term "peripheral fibro-osseous lesion (PFOL)" is used relatively for common gingival lesions characterized histologically by hypercellular connective tissue showing either new bone-like formations or cementum-like substance and rarely dystrophic calcifications. These lesions are closely related to the other fibro-osseous lesions such as cemental periapical dysplasia, fibrous dysplasia, and other calcifying odontogenic cysts and tumors. The etiology is unknown, but certain authors suggest plaque, dental calculus, and ill-fitting dentures which might be the irritating agents causing irritation to the periodontal ligament which leads to such reactive growth.
View Article and Find Full Text PDFArch Oral Biol
November 2024
Laboratory of Histopathology and Immunohistochemistry, School of Dentistry, Universidade Federal do Pará, Belém, Pará, Brazil. Electronic address:
Objective: The study aimed to investigate the expression of hypoxia markers associated with invadopodia in glandular odontogenic cysts and to explore an association between this expression with the aggressive biological behaviour of this odontogenic cyst.
Design: Immunohistochemistry was employed to assess the expression of hypoxia-inducible factor 1 alpha (HIF-1α), notch homologous protein of the neurogenic locus 1 (NOTCH-1), disintegrin and metalloproteinase-12 (ADAM-12), and heparin-binding epidermal growth factor (HB-EGF) in 17 samples of glandular odontogenic cysts, 10 samples of calcifying odontogenic cysts, and 10 samples of dental follicles.
Results: The glandular odontogenic cyst samples exhibited increased expression of HIF-1α, NOTCH-1, ADAM-12 and HBEGF proteins compared with calcifying odontogenic cyst and dental follicle samples.
BMC Oral Health
November 2024
Department of Stomatology, The First Affiliated Hospital of Bengbu Medical University, No. 287, Changhuai Road, Longzihu District, Bengbu City, Anhui Province, 233004, China.
Background: This study aims to analyse the clinical characteristics of different types of odontogenic jawbone cysts (OJCs) and to provide a theoretical basis for prevention and clinical treatment.
Methods: Data from 1,038 patients with OJCs were collected, and relevant information, such as sex, age, clinical symptoms and signs, imaging data, number of lesions, lesion location, pathological diagnosis, clinical treatment and prognosis, was statistically analysed.
Results: According to the World Health Organization (WHO) classification of OJCs in 2022, the highest incidence rate was observed for radicular cysts (RCs), accounting for 58.
J Med Case Rep
November 2024
Department of Oral and Maxillofacial Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Background: Calcifying epithelial odontogenic tumor is a rare benign tumor that predominantly occurs in posterior sites of the mandible in adults.
Case Presentation: This case report describes a case of calcifying epithelial odontogenic tumor in a 37-year-old Iranian female with the chief complaint of swelling in the anterior region of the mandible and tooth displacement. This paper summarized the pathological findings, radiographical features and clinical management of the patient.
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