[Correlative analysis with proliferating cell nuclear antigen,bromodeoxyuridine,and microscopic observation on golden hamster carcinogenesis model].

The early diagnosis of carcinomatous conversion has special significance on increasing effectiveness.Proliferating cell nuclear antigen(PCNA),bromodeoxyuridine(BRDU)(immunohistochemistry ways),and microscopic diagnosis were applied and observed on golden hamster cheek pouch carcinogenisis model induced by dimethybenzanthracene(DMBA) in order to seek simple,effective,leading and reliable diagnostic way.The results showed that three observable means had significant correlation,and demonstrated that immunohistochemistry ways practical value in diagnosis of carcinomatous conversion.This study suggests that PCNA and BRDU are more sensitive,simple and reliable,and two hopeful methods of early diagnosis of carcinomatous conversion.