The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems.
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| http://dx.doi.org/10.1016/j.physbeh.2004.02.014 | DOI Listing |
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Effects of different pre-conditioning exercise on leptin synthesis and its downstream signalling pathway in T2DM rats.
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School of Physical Education, Department of Sports Health, Central China Normal University, Wuhan, 430079, China.
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Materials And Methods: The T2DM model was established using an 8-week high-sugar, high-fat diet combined. The T2DM model was established using an 8-week high-sugar, high-fat diet combined with streptozocin (STZ) injection.
High levels of serum dihomo-γ-linolenic acid are associated with non-alcoholic fatty liver disease in type 2 diabetic patients.
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Division of Diabetes, Metabolism, and Endocrinology, Department of Medicine, Toho University Graduate School of Medicine, Tokyo, Japan.
An elevated level of saturated fatty acids (SFAs) can cause non-alcoholic fatty liver disease (NAFLD). While n-3 polyunsaturated fatty acids (PUFAs) were shown to improve NAFLD, the effects of n-6 PUFAs in the liver have not been fully elucidated. We examined the association between NAFLD and n-6 PUFAs, particularly dihomo-γ-linolenic acid (DGLA), in patients with type 2 diabetes.
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Department of Cardiology, Guizhou Provincial People`s Hospital, 83 Zhongshan East Road, Guiyang City, 550002, Guizhou Province, China.
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View Article and Find Full Text PDFThe influence of high-fat diet on nicotine vapor self-administration, neuronal excitability, and leptin levels in adult mice.
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January 2025
Department of Biomedical Sciences, Joan C Edwards School of Medicine at Marshall University, 1700 3(rd) Avenue, Huntington, WV 25703, USA. Electronic address:
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Department of Medicine, Veterans Affairs Medical Center, Washington, DC, USA.
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