AI Article Synopsis
- Two zinc finger proteins from Trypanosoma cruzi, the parasite causing Chagas disease, have been identified, named tcZFP1 and tcZFP2.
- These proteins possess a unique zinc finger motif (CCCH) that is commonly found in RNA-binding proteins involved in cell regulation.
- The study describes the successful expression of recombinant tcZFP1 and examines how well it binds and remains stable with synthetic oligoribonucleotides that have C-rich sequences.
Article Abstract
We have identified two zinc finger proteins of Trypanosoma cruzi, the protozoan parasite that causes Chagas disease in humans. These proteins, named tcZFP1 and tcZFP2, share the unusual zinc finger motif (CCCH) found in a diverse range of RNA-binding proteins involved in various aspects of the control of cell homeostasis and differentiation. We report here the functional expression of a recombinant tcZFP1, and the relative affinity and stability of the specific complexes formed between the protein and synthetic oligoribonucleotides containing C-rich sequences.
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| http://dx.doi.org/10.1016/j.bbrc.2004.04.162 | DOI Listing |
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