AI Article Synopsis
- The p75 neurotrophin receptor (p75NTR) was identified nearly 20 years ago, but its exact physiological functions are still not fully understood.
- Recent research shows that p75NTR is part of three different receptor platforms that interact with various ligands.
- Depending on the context, p75NTR can promote cell survival, trigger cell death, or inhibit growth, offering new insights into its complex role.
Article Abstract
Although identified almost 20 years ago, the precise physiological role of the p75 neurotrophin receptor (p75NTR) has remained elusive. Recent studies have revealed that p75NTR is a component of three distinct receptor platforms that bind different ligands and that, under differing circumstances, facilitate cell survival, cell death, or growth inhibition. These recent developments provide new insights into the functions of this enigmatic receptor.
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| http://dx.doi.org/10.1016/j.neuron.2004.04.001 | DOI Listing |
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