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Prereplication-complex formation: a molecular double take?
Nat Struct Mol Biol
January 2014
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA.
In G1, two copies of the MCM2-7 helicase are recruited to each origin of replication. Whereas recruitment of the first MCM2-7 is likely to be analogous to the loading of sliding clamps around DNA, how the second MCM2-7 complex is recruited is highly contentious. Here, we argue that MCM2-7 loading involves specific modifications to the clamp-loading reaction and propose that the first and second MCM2-7 molecules are loaded via similar mechanisms.
View Article and Find Full Text PDFEndosymbiosis: double-take on plastid origins.
Curr Biol
September 2006
The Canadian Institute for Advanced Research, Program in Evolutionary Biology, Department of Biochemistry and Molecular Biology, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, Nova Scotia, B3H 1X5, Canada.
Plastids--the light-harvesting machines of plant and algal cells--evolved from cyanobacteria inside a eukaryotic host more than a billion years ago. New data reveal that a mysterious unicellular alga acquired its photosynthetic apparatus much more recently than other eukaryotes, affording a second look at the primary endosymbiotic origin of plastids.
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