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Streptococcus pneumoniae infection is considered an uncommon cause of arthritis in adults. To determine the clinical and microbiological characteristics of pneumococcal septic arthritis, we retrospectively studied a large series of cases among adult patients during the 2010-2018 conjugate vaccine era in France. We identified 110 patients (56 women, 54 men; mean age 65 years), and cases included 82 native joint infections and 28 prosthetic joint infections.
View Article and Find Full Text PDFHospitalization due to pneumococcal disease in the Unified Health System in Brazil: A retrospective analysis of administrative data.
Braz J Infect Dis
November 2024
Secretaria Estadual de Saúde do Espírito Santo, Vitória, ES, Brazil.
Introduction: Community-Acquired Pneumonia (CAP) caused by pneumococcus and Invasive Pneumococcal Disease (IPD) pose a substantial economic burden on health systems. The objective of the present study is to explore hospitalization costs of pneumococcal disease in the public health system in Brazil, the Unified Health System.
Methods: Retrospective analysis of administrative data on hospitalized cases of pneumococcal disease from January 2019 to July 2023.
Pneumococcal Endocarditis in a 49-Year-Old Male With Concomitant Myocarditis, Septic Spinal Arthritis, and Paraspinal Myositis: A Case Report.
Cureus
October 2024
Emergency Medicine, Mayo Clinic, Phoenix, USA.
Pneumococcal infective endocarditis (PIE) is a rare but serious infection often presenting with systemic complications such as septic emboli, myocarditis, and septic arthritis. This case report highlights a 49-year-old male who presented with acute-on-chronic lower back pain and fever, later diagnosed with PIE complicated by septic spinal arthritis, paraspinal myositis, and developing myocarditis. A 49-year-old male presented to the emergency department (ED) with worsening back pain and fever after treatment failure for suspected pyelonephritis.
View Article and Find Full Text PDFImpact of PCV13 and PPSV23 Vaccination on Invasive Pneumococcal Disease in Adults with Treated Rheumatoid Arthritis: A Population-Based Study.
Microorganisms
October 2024
UCONN School of Medicine, Farmington, CT 06030, USA.
On-time receipt of pneumococcal vaccines is essential in patients with rheumatoid arthritis (RA) as immunosuppressive medications increase their risk of invasive pneumococcal disease (IPD). However, data regarding the impact of timely administration of these vaccines on the risk of developing IPD are lacking for RA patients. We conducted a retrospective cohort study to assess the impact of on-time vaccination for pneumococcal conjugate vaccine (PCV) 13 and pneumococcal polysaccharide vaccine (PPSV) 23 in patients treated for RA on the development of IPD using national Veterans Affairs data from 2010 to 2018.
View Article and Find Full Text PDFSecondary Immunodeficiency and Vaccine Response in Rheumatoid and Psoriatic Arthritis on Immunosuppressive Medicines.
Cureus
August 2024
Allergy and Immunology, Rochester Regional Health, Rochester, USA.
Article Synopsis
- Rheumatoid arthritis and psoriatic arthritis patients often have compromised immune systems, which can be worsened by immunosuppressive treatments, potentially leading to secondary immunodeficiency (SID).
- A study involving 42 patients on immunosuppressive medications evaluated their immune parameters and vaccination responses to distinguish SID.
- The results showed a significant percentage of patients had low immunoglobulin levels and exhibited suboptimal responses to vaccinations, particularly to pneumococcal vaccines, indicating that SID may indeed be clinically detectable in these patients.
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