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Methotrexate-induced leukoencephalopathy presenting as acute-onset limb weakness in a child: a case report.
J Med Case Rep
September 2024
Colombo North Teaching Hospital, Ragama, Sri Lanka.
Article Synopsis
- Methotrexate is a key medication for treating childhood cancers like acute lymphoblastic leukemia but can lead to severe side effects such as neurotoxicity, specifically leukoencephalopathy, which usually presents with gradual neurological symptoms.
- A case involving a 10-year-old boy showed acute neurological symptoms, including limb weakness and involuntary movements, after taking oral methotrexate, a rare occurrence compared to traditional administration routes like injection.
- MRI scans revealed brain abnormalities consistent with methotrexate-induced neurotoxicity, highlighting the need for careful monitoring of neurological effects even with oral use of the drug.
Methotrexate (MTX) is used to treat acute lymphoblastic leukemia (ALL). It acts by inhibiting cell proliferation through its role as a folate antagonist. Despite its positive impact on patients' survival, high-dose MTX therapy carries risks, notably neurotoxic side effects such as subacute leukoencephalopathy that can mimic stroke symptoms.
View Article and Find Full Text PDFClinico-radiological profile, management and follow-up of methotrexate induced neurotoxicity in children with acute lymphoblastic leukemia.
Leuk Lymphoma
December 2023
Division of Pediatric Oncology, Department of Medical Oncology, Tata Memorial Hospital, Mumbai, India.
Methotrexate-induced neurotoxicity is a well-defined side-effect of high-dose and intrathecal methotrexate with characteristic clinico-radiological findings and transient nature. Our experience in managing this entity in children with acute lymphoblastic leukemia(ALL) is reported here. All children with de novo ALLregistered from January 2016 through December 2021 who developed methotrexate-induced neurotoxicity were included.
View Article and Find Full Text PDFGood Gone Bad: Complications of Chemotherapy, Immunotherapy, and Radiotherapy on the CNS.
Curr Probl Diagn Radiol
December 2023
Mallinckrodt Institute of Radiology, St. Louis, MO.
Article Synopsis
- New cancer treatments, especially immunotherapy, are helping patients live longer and feel less sick, but there are still problems that can come from these therapies.
- Doctors who look at brain images, called neuroradiologists, can spot signs of these problems early on.
- The article explains various complications from different treatments, like chemotherapy and radiation, and stresses how important it is for doctors to recognize these issues to help patients stay safe and healthy.
Recurrence of methotrexate-induced leukoencephalopathy after methotrexate rechallenge: A case report and literature review.
Radiol Case Rep
March 2023
College of Medicine, Alfaisal University, Takhassusi Rd, Riyadh 11533, Saudi Arabia.
Article Synopsis
- Methotrexate (MTX) is a strong chemotherapy drug used to treat conditions like T-cell lymphoblastic leukemia, but it can cause serious neurological side effects mimicking stroke, known as MTX-induced leukoencephalopathy (LE).
- A case was reported of a 17-year-old male with T-LBL who experienced symptoms of facial drooping and weakness after receiving a dose of MTX, which were confirmed by MRI as MTX-induced LE.
- After recovering, he was treated again with MTX six months later and experienced a recurrence of symptoms, prompting a discussion on the mechanisms behind MTX-induced LE, effective imaging techniques, and potential treatment strategies.
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